The Prognostic Significance of HALP Index for Colon Cancer Patients in a Hispanic-Based Population
Journal
Journal of Oncology
ISSN
1687-8469
1687-8450
Date Issued
2022
Author(s)
Calderillo Ruiz, German
Lopez Basave, Horacio
Vazquez Renteria, Rafael Sebastian
Castillo Morales, Alison
Guijosa, Alberto
Castillo Morales, Carolina
Herrera, Marytere
Diaz, Consuelo
Vazquez Cortes, Ezequiel
Ruiz-Garcia, Erika
Munoz Montano, Wendy R.
Type
text::journal::journal article
Abstract
Background: Survival and recurrence rates following locoregional colon cancer surgical resection are highly variable. Currently used tools to assess patient risk are still imperfect. In the present work, we evaluate, for the first time, the prognostic value of the recently developed HALP (hemoglobin, albumin, lymphocyte, and platelet) index in Hispanic colon cancer patients. Patients and Methods. We conducted a retrospective cohort study in Mexican patients with a nonmetastatic colon cancer diagnosis who underwent surgical resection. We determined the preoperative HALP score optimal cut-off value by using the X-tile software. We plotted survival curves using the Kaplan-Meier method and performed a multivariate Cox regression analysis to explore the association of preoperative HALP score with two primary endpoints: overall survival (OS) and disease-free survival (DFS). Results: We included 640 patients (49.8% female). The optimal HALP cut-off value was 15.0. A low HALP index was statistically significantly associated with a higher TNM stage. Low HALP score was statistically significantly associated with shorter median OS in the Kaplan-Meier analysis (73.5 vs. 84.8 months) and in the multivariate Cox regression analysis (HR = 1.942, 95% CI = 1.647-2.875). There was no significant association between the HALP score and DFS. Copyright © 2022 German Calderillo Ruiz et al. © Journal of Oncology