Extended major histocompatibility complex haplotypes, ancestry and acute kidney transplant rejection in Mexicans
Journal
Revista de Investigación Clínica
ISSN
0034-8376
Date Issued
2011-07
Author(s)
Riquelme Mc Loughlin, M. Constanza
Granados, Julio
Acuña-Alonzo, Víctor
Telich, Eduardo
Mancilla-Urrea, Eduardo
Villa, Antonio R.
De Leo, Claudia
Alberú, Josefina
Morales-Buenrostro, Luis Eduardo
Madero, Magdalena
Type
text::journal::journal article
Abstract
Introduction. Extended major histocompatibility complex (MHC) haplotypes are associated with several autoimmune diseases, and these appear to depend on ancestry. Objective. To evaluate the association of extended MHC gene frequencies, ancestry, and acute rejection. Material and methods. 127 living kidney transplant recipients who underwent kidney transplantation in Mexico City between January 2004 and October 2007 with follow up until October 2008. The primary outcome was biopsy proven acute rejection. Ancestry was considered as either Amerindian or admixtures with Caucasian, African or Oriental genes. Allele and haplotype frequencies were estimated for HLA A, B and DR loci. Hardy Weinberg (HW) and delta values were analyzed to test for linkage disequilibrium (LD).© Revista de Investigación Clínica