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Pediatric conjunctival melanoma: A comprehensive case report and literature review
(Elsevier, 2024)
Cantú-Soriano, Gonzalo N.
;
Sánchez, N. G.
;
Suárez-Reynoso, L.
;
Padilla Rodríguez, Álvaro Lezid
Purpose: This case report aims to present a rare instance of conjunctival melanoma in a 5-year-old patient and contribute to the limited body of knowledge on pediatric conjunctival melanoma. The purpose is to understand the characteristics, diagnosis, and management of this uncommon malignancy in young individuals. Observations: The case describes a 5-year-old female with a progressively growing pigmented conjunctival lesion. The lesion was observed to be located on the temporal conjunctiva of the right eye and displayed distinctive features, including feeder vessels. Imaging revealed specific dimensions of the lesion and ruled out deeper invasions. Histopathological examination revealed architectural and cytologic atypia, positive immunohistochemical staining for HMB-45, and a Ki67 proliferation index of 20 %, confirming the diagnosis of conjunctival melanoma. ©American Journal of Ophthalmology Case Reports.
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Tumor fibroso calcificante intestinal: reporte de caso
(Elsevier, 2023)
Cantú-Soriano, Gonzalo Nathaniel
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Padilla Rodríguez, Álvaro Lezid
Calcifying fibrous tumor (CFT) is a rare benign lesion of mesenchymal origin that may present similar characteristics to other more common tumors. We present the case of a 36-year-old woman with a tumor in the proximal jejunum, initially suspected to be a gastrointestinal stromal tumor (GIST). Surgical resection was performed, revealing a well-demarcated nodule at the anti-mesenteric border with microscopic features typical of a calcifying fibrous tumor. The tumor cells were positive for CD34 and negative for other markers, differentiating it from other neoplasms. Calcifying fibrous tumors can be confused with more common tumors because of its appearance, but an accurate diagnosis supported by immunohistochemistry is essential. Complete surgical excision is usually curative. © 2023 Sociedad Española de Anatomía Patológica. ©Elsevier
9 1
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Cutaneous Angiomyolipoma—a distinct entity that should be separated from classic Angiomyolipoma: complete review of existing cases and defining fundamental features
(2022)
Sánchez, Natalia Gabriela
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Ávila Romay, Alfonsina Angelica
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Martínez Luna, Eduwiges
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Padilla Rodríguez, Álvaro Lezid
Cutaneous angiomyolipoma is a rare mesenchymal tumor that is demographically, clinically, and immunohistochemically distinct from its renal and extrarenal counterparts. We present a case of cutaneous angiomyolipoma in the right retroauricular area of a 35-year-old male patient and provide a broad systematic review of the literature and the largest compilation of cutaneous angiomyolipomas reported to date. According to the findings presented in this review, we conclude that cutaneous angiomyolipoma should be completely separated from renal and extrarenal angiomyolipomas and therefore be considered a distinct entity in the classification of skin tumors. ©The authors, JMIR Dermatology
Scopus© Citations 2 20 1
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Enfermedad de Kikuchi-Fujimoto (linfadenitis histocítica necrosante). Estudio clinicopatológico e inmunohistoquímico de 14 casos y su diagnóstico diferencial con otras linfadenitis necrosantes reactivas y neoplásicas
(2006-09)
Gutiérrez-Castro, Macrina
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De León-Bojorque, Beatriz
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Cuesta-Mejías, Teresa
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Baquera-Heredia, Javier
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Padilla Rodríguez, Álvaro Lezid
Kikuchi-Fujimoto disease also known as histiocytic necrotizing lymphadenopaty (HNL) is a rare entity, originally described in Japanese population, although currently it has been described all over the world. It is more frequent in young women and it is usually located in cervical lymph nodes. We report 14 cases of HNL in Mexican population, their clinicopathological and immunohistochemical study as well as a comparative study with other necrotizing lymphadenopaties due to B or T-cell lymphomas, tuberculosis, Epstein Barr virus infection, and non-specific necrosis. In our study we found that there was more expression of the immunomarkers CD68, MPO, CD123 and antikerat in OSCAR in the cases of HNL in contrast with the lesser or even null expression of the same markers in the necrotized lymph nodes of the comparative study group.
Scopus© Citations 7 9 2
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Carcinoma seroso micropapilar invasor. Informe de un caso bilateral de ovario
(2007-11)
Espinosa de los Monteros Franco, Vladimir Abdel
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Padilla Rodríguez, Álvaro Lezid
A subject that has been very controvertial in the last few years in the field of the surgical pathology has been the terminology and the concept of borderline serous tumor of ovary (TSL). Recently the term of micropapillary serous carcinoma was introduced (CSMP) to define a subtype of serous tumors that are characterized for a micropapillary grow pattern and that clinically associated with a more aggressive behavior than the classic TSL since they have an increased risk of invasion, recurrence and extraovarian tumor implantation. The majority of these cases are included within the serous bordering tumors of ovary, being the truly invasive tumors even more infrequent and with more aggressive clinical course. We reported the case of a 52 years old woman with bilateral invasive micropapillary serous carcinoma of ovary. ©Ginecología y Obstetricia de México
Scopus© Citations 1 20 1
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Linfoma no Hodgkin anaplásico de células T primario cutáneo rico en neutrófilos y eosinófilos. Estudio inmunohistoquímico de una variante poco frecuente
(2008-01)
Martínez Consuegra, Nayeli
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Moreno Collado, Clemente
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Padilla Rodríguez, Álvaro Lezid
Anaplastic large cell lymphoma (LACG) is a T-cell lymphoma of pleomorphic CD30-positive cells. According to the expression of the chimeric protein ALK, LACG can be divided into three groups: systemic LACG ALK-positive, systemic LACG ALK-negative, and primary cutaneous LACG ALK-negative. According to the new WHO/EORTC classification, primary cutaneous LACG is included in the cutaneous T-cell lymphoproliferative disorders. We report an infrequent variant of primary cutaneous LACG. A 54-year old man presented with a 5 cm mass in the skin of his right gluteus, which had been present for six months without systemic involvement. Histological findings revealed a diffuse dermal infiltration of large CD3, CD43, CD30-positive, ALK-negative T-cells. Mixed with the neoplastic cells, there was a profuse infiltrate of neutrophils and eosinophils, establishing the diagnosis of neutrophil and eosinophil-rich primary cutaneous LACG. The presence of an increased number of neutrophils and/or eosinophils without necrosis, ulceration or infection is a rare finding in lymphomas, even more rare is the location in the skin of which only 16 cases have been reported in the literature. It is important to be aware of these findings in the differential diagnosis with other reactive or neoplastic entities that are more often accompanied by mixed inflammatory infiltrate, and with a different prognosis and treatment.© Dermatología Revista Mexicana
24 2
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Apéndice triluminal septado: Una variante morfológica de septo con muscularis propria
(2023)
Sánchez, N.G.
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Estrada-Ortíz, F. A.
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Peñarrieta-Daher, A.A.
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Padilla Rodríguez, Álvaro Lezid
Las malformaciones del apéndice son extremadamente raras y usualmente son un hallazgo incidental1. Los apéndices septados solamente se han descrito en una serie de casos que reportó 25 casos de septos conformados por submucosa, sin muscularis propria2. Presentamos el primer caso de apéndice septado con cada luz separada por septos con muscularis propria. ©Revista de Gastroenterología de México
24 1
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Intra-abdominal Follicular Dendritic Cell Sarcoma With Marked Pleomorphic Features and Aberrant Expression of Neuroendocrine Markers: Report of a Case With Immunohistochemical Analysis
(2007)
Padilla Rodríguez, Álvaro Lezid
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Bembassat, Miguel
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Lopez, Miguel
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Follicular dendritic cell sarcoma (FDCS) is a very rare malignant tumor arising most frequently in lymph nodes with only few reports of extranodal locations. We report the case of a 35-year-old man with a large retroperitoneal mass. Histologically the tumor was composed of highly pleomorphic cells exhibiting some uncommon features such as an epithelioid appearance, cystic spaces, and multinucleated cells with morphologic features of emperipolesis. Immunohistochemically the neoplastic cells were immunoreactive for CD21, CD23 and CD35. A previously unreported expression of neuroendocrine markers (Synaptophisyn and Neuron-Specific-Enolase) was present. Ultrastructurally no neuroendocrine secretory granules were detected. FDCS can mimic a wide variety of other malignant tumors, and a correct diagnosis requires exclusion of other neoplasms and immunohistochemical confirmation. © 2007 Lippincott Williams & Wilkins, Inc.
Scopus© Citations 16 11 1
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Synchronous Benign and Malignant Mesenchymal Breast Tumor
(2007)
Padilla Rodríguez, Álvaro Lezid
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Padilla-Villalta, Alfonso
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Arandia, Yanitza
A 45-year-old woman presented with a 3-month history of right breast mass. Clinical examination revealed a firm mass in the right upper outer quadrant of the breast. Ultrasonography revealed a hypoechogenic circumscribed solid mass. An 11 cm-sized tumor was surgically removed. © The Breast Journal
Scopus© Citations 1 9 1
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Pure hibernoma of the breast: insights about its origins
(2012)
Padilla Rodríguez, Álvaro Lezid
Hibernomas are rare benign tumors composed of cells reminiscent of brown adipose tissue. In the mammary gland, hibernomas are extraordinary rare, with only 4 cases reported previously. We report the fifth case in a 37-year-old woman who presented with a slowly growing mobile mass in her right breast. A 2.2 cm well-circumscribed lobulated mass was completely removed. The histopathologic analysis showed the full characteristics of the hibernoma. A review of the clinicopathologic features of hibernomas, its relation to brown adipose tissue in humans, and considerations about its histogenesis are made.
Scopus© Citations 7 19 2

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