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Primary Angiomatoid Melanoma as an Exceptional Morphologic Pattern in Cutaneous Melanoma. A Case Report and Review of the Literature
(Elsevier, 2015)
Ramos-Rodríguez, Guillermo
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We report a case of angiomatoid melanoma on the right thigh of a 59-year-old man. The histologic growth pattern of the tumor mimicked vascular proliferation, and the cells lining the pseudovascular spaces were positive for protein S-100, HMB-45, and MITF-1. The differential diagnosis is with angiosarcoma and pseudovascular adenoid squamous cell carcinoma. The case we present is the fifth reported to date. © 2014 Elsevier España, S.L.U. and AEDV. All rights reserved.
Scopus© Citations 6 11 1
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Traumatic and compressive lesions of peripheral nerves
(2014)
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Weller, Roy O.
Injuries to peripheral nerves range from acute and chronic compression, to entrapment and traumatic transection. Clinically, traumatic lesions present with loss of sensation and muscle power; electrophysiology is used to localize lesions and to determine their nature and extent. Pathology of traumatic lesions ranges from myelin displacement and demyelination in compressive lesions to complete transection of nerves associated with penetrating injuries and fractures. Entrapment of peripheral nerves occurs in bony or muscle and ligamentous tunnels, particularly in older age groups with damage to nerves from stretching, restriction of movement and deprivation of blood supply. Focal lesions that result from trauma to peripheral nerves described here include traumatic neuromas, Morton's neuroma, reactive perineurial hyperplasia and focal hypertrophic neuropathy. Copyright © 2014 International Society of Neuropathology.
12 1
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Myopericytoma in an unusual location
(2018)
Ruiz-Arriaga, Leon Felipe
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Ramírez Terán, Ana Laura
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Fonte-Avalos, Verónica
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Toussaint-Caire, Sonia
Myopericytoma is a soft-tissue tumor of perivascular cells (pericytes). It is slow-growing, usually asymptomatic, and generally benign, although a malignant variant has been described. The etiology is unknown, but it has been associated with local trauma. The most common location is on the distal extremities. Histologically, it is characterized by a well-circumscribed, non-encapsulated proliferation of spindle shaped cells similar to myofibroblasts with oval nuclei and eosinophilic cytoplasm, arranged in perivascular concentric rings. There are few mitoses and no necrosis is reported. The immunohistochemical analysis is positive for smooth muscle actin and negative or weakly positive for desmin. A low Ki-67 proliferation index is typical. Treatment is surgical excision with free margins. Recurrences after adequate excision are uncommon. We describe a 48-year-old woman with a myopericytoma in an unusual location (next to the inner corner of her left eye) who was treated with surgical excision; there has been no recurrence after 5 years of follow up. © 2018, Dermatology Online Journal. All rights reserved.
Scopus© Citations 6 20 2
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Carcinoma epidermoide orofaríngeo metastásico en ganglios linfáticos cervicales asociado a los subtipos 16 y 45 del virus del papiloma humano (VPH). estudio clínico, morfológico y molecular de dos casos
(2013)
Soria-Céspedes, Danny
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Canchola Aguilar, Guadalupe
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Lara-Torres, César Octavio
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Sánchez-Marle, Juan Felipe
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Hernández-Peña, Roberto Enrique
Human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma has been identified as a distinct entity within squamous cell carcinoma of the head and neck. In contrast to carcinomas associated with alcohol and/or tobacco, this subtype occurs at younger age, with frequent absence of classic risk factors, correlation with oral sexual habits, strong predilection for the palatial tonsils and the base of the tongue (lingual tonsils), basaloid or lymphoepithelial differentiation, higher degree of radiosensitivity, and overall better survival. We report two cases of lymph node, metastatic, poorly differentiated squamous cell carcinoma that were positive by immunohistochemistry for p16 with detection of HPV-16 and HPV-45 by PCR. (Gac Med Mex. 2013;149:673-9) © Gaceta Médica de México
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Peripheral Nervous System
(2019-07)
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Weller, Roy O.
From a practical point of view, the pathology of peripheral nerves falls into two main categories: (a) peripheral neuropathies, which are diagnosed and treated by physicians and for which an elective nerve or muscle biopsy may be performed as a diagnostic procedure rather than as a therapeutic exercise, and (b) tumors and traumatic lesions, which are removed surgically mainly as a therapeutic measure to alleviate symptoms. For the diagnosis of peripheral neuropathies, a detailed knowledge of the structure, immunohistochemistry and ultrastructure of peripheral nerves. The diagnosis of tumors and more on identifying the cellular their interrelationships. This chapter, therefore, concentrates first on how to identify different cellular components in normal peripheral nerves, and second, on how knowledge of the normal structure of peripheral nerves can be used to identify and assess pathologic lesions. © Wolters Kluwer
236 1
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Comparación inmunohistoquímica entre la GCDFP-15 y los receptores para estrógenos y progesterona en el diagnóstico de carcinoma metastásico de la mama
(2012-05)
Villarroel Salinas, Jaime
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Soria Céspedes, Danny
Antecedentes: en el estudio de tumores de sitio primario no conocido en mujeres, una consideración frecuente es carcinoma mamario, porque puede presentarse como metástasis. Objetivo: describir y comparar el patrón inmunohistoquímico de los receptores hormonales (receptor de estrógenos [RE] y receptor de progesterona [RP]) y GCDFP-15 en carcinoma mamario metastásico en ganglio linfático según el grado histológico. Métodos: estudio retrospectivo donde se analizan 30 casos de carcinoma mamario con metástasis ganglionar, divididos en tres grupos: grado I (bien diferenciado), grado II (moderadamente diferenciado) y grado III (poco diferenciado). Se utilizaron tres anticuerpos (RE, RP y GCDFP-15) en el ganglio linfático y se comparó su expresión según el grado histológico. Resultados: en ganglios linfáticos con metástasis de carcinoma mamario grado I los receptores hormonales fueron positivos en el 100% y GCDFP-15 en el 80%. En grado II, el RE y el RP fueron positivos en el 90 y 40%, respectivamente, y GCDFP-15 en el 80%. En grado III, el RE y RP fueron positivos en el 30 y 50%, respectivamente, y GCDFP-15 en el 60%. ©Gaceta Médica de México
Scopus© Citations 3 8 2
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Águeda de Catania: Santa patrona de las enfermedades de la glándula mamaria
(2011-09)
For those suffering from breast cancer, Agatha is their patron saint. She was a beautiful Christian maiden, from Catania, Sicily, who dedicated her life to God. As she rejected the love proposals of consul Quintiliano, she suffered cruel tortures. One of the tortures she suffered was to have her breast cut off, with iron shears, a detail that furnished to the Christian medieval iconography, the peculiar characteristic of Agatha. Catania honors Agatha as her patron saint and throughout the region around Mt. Etna. Saint Agatha’s feast day is February 5. All of those dedicated to the treatment and prevention of breast cancer are known as “the soldiers of Saint Agatha”.© Gaceta Médica de México.
Scopus© Citations 2 39 1
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Melanoma primario cutáneo angiomatoide. Un patrón morfológico excepcional en los melanomas de piel. Presentación de caso con revisión de la literatura
(Elsevier, 2015)
Ramos-Rodríguez, Guillermo
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Presentamos un caso de melanoma angiomatoide localizado en la piel del muslo derecho en un hombre de 59 años de edad. La neoplasia mostró un patrón de crecimiento semejante a una proliferación vascular donde las células que revestían esos espacios “pseudovasculares” fueron positivas a la proteína S-100, al HMB45 y al MiTF1. El diagnóstico diferencial incluye el angiosarcoma y el carcinoma escamoso pseudovascular. El caso que aquí informamos es el quinto de la literatura mundial.
Scopus© Citations 3 10 2
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George H. Whipple. Premio Nobel en Fisiología y Medicina en 1934. La enfermedad de Whipple, la anemia perniciosa y otras contribuciones a la medicina
(2002-07)
George Hoyot Whipple (1878-1976) was awarded the Nobel Prize in Physiology and Medicine in 1934, along with Minot and Murphy for their studies in pernicious anemia. Whipple's name has been given to the bacterial disease which he describes in 1907 that we know today as Whipple's disease or intestinal lipodystrophy. He gave the name of thalasemia to the Mediterranean anemia of Cooley, and made diverse contributions to hematology and general pathology. He worked with William Welch in the Department of Pathology at Johns Hopkins Hospital and later became director of the University of Rochester. He died in 1976 at the age of 98.© Gaceta Medica de México
Scopus© Citations 3 37 1
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Enfermedad de Rosai-Dorfman, limitada a la piel. Informe de cuatro casos
(2003-01)
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Cuesta Mejías, Teresa Cristina
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Ochoa Ochoa, Concepción
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Valenzuela Espinosa, Alfonso
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Toussaint Caire, Sonia
Sinus histiocytosis with massive lymphadenopathy (SHML), or Rosai-Dorfman Disease, presents with bilateral painless cervical adenomegaly, fever, and several hematologic abnormalities. Skin is the extranodal site most frequently affected. We described four additional cases of SHML limited to the skin, emphasizing possible confusion with other dermatoses. Clinical, morphologic, and immunohistochemical aspects of four patients with cutaneous SHLM, three diagnosed in the ABC Medical Center in Mexico City and the other at the Hermanos Ameijeiras Hospital of Havana, Cuba, are reviewed. Three males and one female, 48, 35, 42, and 55 years of age, presented with chronic asymptomatic dermal nodules, papules, or plaques on trunk, extremities, and face. Skin biopsies showed dense infiltrates of foamy histiocytes, lymphocytes, and plasma cells; histiocytes presented with prominent emperipolesis and intense S100 and CD68 immunostain. The four cases reported here had histiocytic benign proliferative disorder corresponding with cutaneous SHML: Emperipolesis suggested the diagnosis. Immunohistochemistry demonstrated positivity for S100 protein in macrophages. Cutaneous lesions of SHML are easily recognized when they are found in the classical clinical picture, but as purely skin disease could be confused with other dermatoses. ©Gaceta Médica de México
Scopus© Citations 2 34 2

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