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Item type:Publication, Pathological and Immunohistochemical Features of Malignant Peripheral Nerve Sheath Tumor With Heterologous Rhabdomy Oblastic Differentiation (Malignant Triton Tumor) in the Context of the Malignant Peripheral Nerve Sheath Tumor Spectrum(SAGE Publications, 2025-12-17) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Los secretos de la cocina del Castillo de Tübingen: Friedrich Miescher y el descubrimiento de la nucleína, piedra angular del ADN(Publicidad Permanyer, 2024)En 1869, Friedrich Miescher, nacido en Basilea, Suiza, descubrió una sustancia rica en fósforo, hasta entonces desconocida, en los núcleos de las células del pus. Al realizar su investigación en un laboratorio instalado en la cocina del castillo medieval de Tübingen, en Alemania, y bajo la dirección del profesor Felix Hoppe-Seyler, Miescher se centró principalmente en la composición de los núcleos celulares. Obtuvo material nuclear de las células del pus de vendajes quirúrgicos proporcionados por un hospital cercano. En 1869, Miescher describió una molécula nuclear completamente nueva que, a diferencia de las proteínas, contenía grandes cantidades de fósforo. Llamó a esta sustancia “nucleína”, con lo que marcó la primera descripción del ADN. Miescher falleció mucho antes de que Watson, Crick, Wilkins y Franklin anunciaran, en 1953, el papel preciso que desempeñaba el ADN en las células. A través de su descubrimiento, Miescher sentó las bases para todas las investigaciones posteriores sobre el ADN. ©El autor. ©Gaceta Médica de México. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, History of Leukemia, Revisited(Springer Science and Business Media LLC, 2025)Purpose of the Review: Provide a general historical overview of leukemia, emphasizing the early discoveries that led to its characterization. Recent Findings: Leukemia recognition began in the late 19th century with the advent of the microscope. Leeuwenhoek and Swammerdam described erythrocytes, while Lieutaud first observed globuli albicantes, later identified as lymphocytes by Hewson. Early case studies by Velpeau, Donné, Bennett, Craigie, Virchow, and Fuller suggested that leukocytosis could occur without infection. Virchow coined the term “leukemia,” while Bennett proposed “leucocythemia.” Neumann identified the bone marrow as the source of blood cells and leukemia, coining the term “myelogenous leukemia,” and Ehrlich classified leukemia into myeloid and lymphoid types. In 1914, Boveri linked chromosomal abnormalities to cancer, and in 1960, Nowell and Hungerford discovered the Philadelphia chromosome. The use of mustard gas in WWI led to the development of chemotherapy drugs like chlorambucil and busulfan. The Human Genome Project further advanced leukemia diagnosis and treatment. Summary: Leukemia, like many diseases, has evolved due to changes in causative factors such as viruses, bacteria, and genetic mutations, which have impacted its pathogenesis and treatment. It will undoubtedly continue to evolve, with new scientists working towards a cure for this devastating disease. ©The author ©Current Oncology Reports ©Springer Science and Business Media LLC. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Primary Angiomatoid Melanoma as an Exceptional Morphologic Pattern in Cutaneous Melanoma. A Case Report and Review of the Literature(Elsevier, 2015)Scopus© Citations 6 11 1 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Traumatic and compressive lesions of peripheral nerves(2014); Weller, Roy O.Injuries to peripheral nerves range from acute and chronic compression, to entrapment and traumatic transection. Clinically, traumatic lesions present with loss of sensation and muscle power; electrophysiology is used to localize lesions and to determine their nature and extent. Pathology of traumatic lesions ranges from myelin displacement and demyelination in compressive lesions to complete transection of nerves associated with penetrating injuries and fractures. Entrapment of peripheral nerves occurs in bony or muscle and ligamentous tunnels, particularly in older age groups with damage to nerves from stretching, restriction of movement and deprivation of blood supply. Focal lesions that result from trauma to peripheral nerves described here include traumatic neuromas, Morton's neuroma, reactive perineurial hyperplasia and focal hypertrophic neuropathy. Copyright © 2014 International Society of Neuropathology.12 1 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Primary Cutaneous Anaplastic Large Cell Lymphoma—A Review of Clinical, Morphological, Immunohistochemical, and Molecular Features(MDPI, 2023); Pina-Oviedo, SergioPrimary cutaneous anaplastic large cell lymphoma (ALCL) is the second most common cutaneous T-cell lymphoma after mycosis fungoides and belongs to the spectrum of cutaneous CD30+ T-cell lymphoproliferative disorders. Although primary cutaneous ALCL usually presents as a localized nodule or papule with or without ulceration, multifocal lesions may occur in up to 20% of cases. Histologically, primary cutaneous ALCL consists of a diffuse dermal infiltrate of medium to large anaplastic/pleomorphic cells with abundant amphophilic-to-eosinophilic cytoplasm, horseshoe-shaped nuclei, strong and diffuse expression of CD30, and with focal or no epidermotropism. The neoplastic infiltrate may show angiocentric distribution and may extend to the subcutis. Patients with localized or multifocal disease have a similar prognosis with a 10-year overall survival rate of 90%. Approximately 30% of primary cutaneous ALCLs harbor a DUSP22 (6p25.3) gene rearrangement that results in decreased expression of this dual-specific phosphatase, decreased STAT3 activation, and decreased activity of immune and autoimmune-mediated mechanisms regulated by T-cells. © CancersScopus© Citations 6 9 2 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Myopericytoma in an unusual location(2018); Scopus© Citations 6 20 2 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Carcinoma epidermoide orofaríngeo metastásico en ganglios linfáticos cervicales asociado a los subtipos 16 y 45 del virus del papiloma humano (VPH). estudio clínico, morfológico y molecular de dos casos(2013)13 1 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Peripheral Nervous System(2019-07); Weller, Roy O.From a practical point of view, the pathology of peripheral nerves falls into two main categories: (a) peripheral neuropathies, which are diagnosed and treated by physicians and for which an elective nerve or muscle biopsy may be performed as a diagnostic procedure rather than as a therapeutic exercise, and (b) tumors and traumatic lesions, which are removed surgically mainly as a therapeutic measure to alleviate symptoms. For the diagnosis of peripheral neuropathies, a detailed knowledge of the structure, immunohistochemistry and ultrastructure of peripheral nerves. The diagnosis of tumors and more on identifying the cellular their interrelationships. This chapter, therefore, concentrates first on how to identify different cellular components in normal peripheral nerves, and second, on how knowledge of the normal structure of peripheral nerves can be used to identify and assess pathologic lesions. © Wolters Kluwer236 1 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Comparación inmunohistoquímica entre la GCDFP-15 y los receptores para estrógenos y progesterona en el diagnóstico de carcinoma metastásico de la mama(2012-05); Soria Céspedes, DannyAntecedentes: en el estudio de tumores de sitio primario no conocido en mujeres, una consideración frecuente es carcinoma mamario, porque puede presentarse como metástasis. Objetivo: describir y comparar el patrón inmunohistoquímico de los receptores hormonales (receptor de estrógenos [RE] y receptor de progesterona [RP]) y GCDFP-15 en carcinoma mamario metastásico en ganglio linfático según el grado histológico. Métodos: estudio retrospectivo donde se analizan 30 casos de carcinoma mamario con metástasis ganglionar, divididos en tres grupos: grado I (bien diferenciado), grado II (moderadamente diferenciado) y grado III (poco diferenciado). Se utilizaron tres anticuerpos (RE, RP y GCDFP-15) en el ganglio linfático y se comparó su expresión según el grado histológico. Resultados: en ganglios linfáticos con metástasis de carcinoma mamario grado I los receptores hormonales fueron positivos en el 100% y GCDFP-15 en el 80%. En grado II, el RE y el RP fueron positivos en el 90 y 40%, respectivamente, y GCDFP-15 en el 80%. En grado III, el RE y RP fueron positivos en el 30 y 50%, respectivamente, y GCDFP-15 en el 60%. ©Gaceta Médica de MéxicoScopus© Citations 3 8 2