Participation of Mesenchymal Stem Cells in the Tumor Process
Journal
Handbook of Stem Cell Applications
Publisher
Springer Nature Singapore
Date Issued
2024
Author(s)
Cisneros, Bulmaro
Type
text::book::book part
Abstract
Although most mesenchymal stem cell (MSCs) studies have focused on evaluating the safety and efficacy of their use as therapeutic agents in regenerative medicine, some recently published studies have highlighted the immunomodulatory role of MSCs in several pathologies, such as cancer. Multiple authors support the idea that MSCs play an essential role in tumor pathogenesis because MSCs can promote and facilitate tumor growth, angiogenesis, and metastasis. Additionally, MSCs may induce modulation of the immune response in favor of tumor growth by producing molecules such as cytokines, growth factors, and immunosuppressive molecules. Despite multiple underlying mechanisms by which MSCs promote tumor development and progression have been described, few reports have defined the mechanisms through which MSCs support immunosuppression. This chapter will present an overview analyzing the immunomodulatory properties of normal and tumor MSCs and their differences because the study of mechanisms that T-MSCs use to regulate the immune response could allow the design and development of novel strategies against cancer. ©The authors ©Springer.
License
Acceso Restringido
How to cite
Arenas-Luna, V.M., Cisneros, B., Hernández-Gutiérrez, S. (2024). Participation of Mesenchymal Stem Cells in the Tumor Process. In: Haider, K.H. (eds) Handbook of Stem Cell Applications. Springer, Singapore. https://doi.org/10.1007/978-981-99-7119-0_37