Enfermedad de Castleman. Análisis histopatológico e inmunohistoquímico de treinta y nueve casos
Journal
Gaceta Médica de México
ISSN
0016-3813
Date Issued
2017
Author(s)
Brisa Sevilla-Lizcano, Diana
Frias-Soria, Christian Lizette
Type
text::journal::journal article
Abstract
Introduction: Castleman disease (CD) is a rare lymphoproliferative that comprises two distinct clinical subtypes (unicentric and multicentric) and has two basic histopathology patterns that are hyaline-vascular (HV) and plasma-cell (PC) type. Some cases of multicentric PC disease are associated with HHV-8 infection. Objective: To present the histopathologic and immunohistochemical characteristics of 39 cases of CD. Methods: A review of cases with the diagnosis CD from the files of the Department of Pathology of the ABC Medical Centre in Mexico City was performed. Thirty-nine cases of CD were identified, and a detailed paraffin immunophenotypic study of 9 of them was completed using desmin, cytokeratin OSCAR (CO) and Epidermal growth factor receptor (EGFR), to evaluate the dendritic cell population. ©Gaceta Médica de México.