Primary Monophasic Synovial Sarcoma of the Tonsil: Immunohistochemical and Molecular Study of a Case and Review of the Literature

Soria-Céspedes, Danny; Galván-Linares, Aldo Iván; Oros-Ovalle, Cuauhtémoc; Gaitan-Gaona, Francisco; Ortíz Hidalgo, Carlos Federico

doi:10.1007/s12105-013-0440-5

Primary Monophasic Synovial Sarcoma of the Tonsil: Immunohistochemical and Molecular Study of a Case and Review of the Literature

Journal

Head and Neck Pathology

ISSN

1936-055X

1936-0568

Date Issued

2013

Author(s)

Soria-Céspedes, Danny

Galván-Linares, Aldo Iván

Oros-Ovalle, Cuauhtémoc

Gaitan-Gaona, Francisco

Ortíz Hidalgo, Carlos Federico

Facultad de Ciencias de la Salud - CampCM

Type

text::journal::journal article

DOI

10.1007/s12105-013-0440-5

URL

https://scripta.up.edu.mx/handle/20.500.12552/2374

Abstract

Synovial sarcoma (SS) arises primarily in the lower extremities with a predilection for sites in proximity to large joints, such as the knee. It rarely occurs in the head and neck region, and the tonsil is an unusual site for the tumor, with only eight previously published cases in this anatomical site. We present a case of a primary monophasic SS arising in the right tonsil in a 63-year-old male. His medical history was noncontributory. Immunohistochemistry showed that cytokeratin OSCAR, EMA, Bcl-2, vimentin, PGP 9.5, and TLE1 were diffusely positive. A molecular analysis using RT-PCR indicated that the patient was positive for the SYT/SSX1 fusion transcript. A diagnosis of monophasic synovial sarcoma of the tonsil was made. © Head and Neck Pathology