Meduloepitelioma pigmentado maligno intraocular. Presentación de dos casos

Soria-Céspedes, Danny; Martínez-Madrigal, Fernando; Méndez-Sashida, Pedro; Ortíz Hidalgo, Carlos Federico

doi:10.1016/S1699-8855(09)70187-4

Meduloepitelioma pigmentado maligno intraocular. Presentación de dos casos

Journal

Revista Española de Patología

ISSN

1699-8855

Date Issued

2009

Author(s)

Soria-Céspedes, Danny

Martínez-Madrigal, Fernando

Méndez-Sashida, Pedro

Type

Resource Types::text::journal::journal article

DOI

10.1016/S1699-8855(09)70187-4

URL

https://scripta.up.edu.mx/handle/20.500.12552/2454

Abstract

Intraocular medulloepithelioma is a rare embryonal tumour that occurs most often in the ciliary body, but may also arise from the iris, retina or optic nerve. We present two cases of pigmented malignant intraocular medulloepithelioma; one teratoid (with hyaline cartilage as a heterologous element), and one non-teratoid. Histochemistry showed the neoplastic cells synthesizing both an acidic substance that stained positive with alcian blue and melanin pigment positive for Fontana- Masson stain. Immunohistochemistry showed positive staining for markers of several lines of differentiation including neuroepithelial (S100 protein, synaptophysin), glial (GFAP), mesenchymal/muscle (vimentin, desmin), epithelial (cytokeratin AE1/3, EMA) and melanocytic (HMB-45, Melan-A). Intraocular medulloepithelioma is composed of multipotential cells capable of polyimmunophenotypic expression. © Revista Española de Patología