Cutaneous sclerosing perineurioma of the digits: an uncommon soft-tissue neoplasm. Report of two cases with immunohistochemical analysis

Canales-Ibarra, Claudia; Magariños, Gabriel; Olsoff-Pagovich, Paul; Ortíz Hidalgo, Carlos Federico

doi:10.1034/j.1600-0560.2003.00108.x

Cutaneous sclerosing perineurioma of the digits: an uncommon soft-tissue neoplasm. Report of two cases with immunohistochemical analysis

Journal

Journal of Cutaneous Pathology

ISSN

0303-6987

Date Issued

2003

Author(s)

Canales-Ibarra, Claudia

Magariños, Gabriel

Olsoff-Pagovich, Paul

Ortíz Hidalgo, Carlos Federico

Facultad de Ciencias de la Salud - CampCM

Type

text::journal::journal article

DOI

10.1034/j.1600-0560.2003.00108.x

URL

https://scripta.up.edu.mx/handle/20.500.12552/2523

Abstract

Background: Cutaneous sclerosing perineurioma is a recently characterized, uncommon tumor composed of perineurial cells, which exhibits immunoreactivity for epithelial membrane antigen (EMA). These lesions occur preferentially in children and young adults and usually develop as dermal or subcutaneous nodules in the hands or palms. Methods: We report two cases of cutaneous sclerosing perineurioma in young patients without stigmata of neurofibromatosis. Histologically, these lesions were well-circumscribed masses and were characterized by a variable number of epithelioid and spindle cells with wavy nuclei end elongated cytoplasmic processes embedded in a dense collagen stroma. © Journal of Cutaneous Pathology