Ortíz Hidalgo, Carlos Federico

Main Affiliation

Preferred name

Official Name

Ortíz Hidalgo, Carlos Federico

ORCID

0000-0002-2456-7402

Researcher ID

DWN-7833-2022

Scopus Author ID

7003618204

Now showing 1 - 10 of 73

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Pathological and Immunohistochemical Features of Malignant Peripheral Nerve Sheath Tumor With Heterologous Rhabdomy Oblastic Differentiation (Malignant Triton Tumor) in the Context of the Malignant Peripheral Nerve Sheath Tumor Spectrum
(SAGE Publications, 2025-12-17)
Luis Felipe Arias-Ruiz
;
<jats:p>Malignant peripheral nerve sheath tumors (MPNST) are aggressive sarcomas arising from Schwann cells or neurofibromas, comprising ∼10% of soft tissue sarcomas. Found in 8% to 13% of neurofibromatosis type 1 patients, they typically show spindle cells expressing S100 and SOX10. Some display heterologous differentiation (bone, cartilage, vessels, or glands). When rhabdomyosarcomatous features are present, they are called malignant peripheral nerve heath tumor with heterologous rhabdomyoblastic differentiation (malignant triton tumors), which are more prone to recurrence, metastasis, and worse outcomes. Epithelial differentiation does not affect prognosis. Despite advances in understanding MPNST biology, many pathophysiological mechanisms remain unclear. This review highlights their histopathology, focusing on malignant triton tumor.</jats:p>
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History of Leukemia, Revisited
(Springer Science and Business Media LLC, 2025)
Purpose of the Review: Provide a general historical overview of leukemia, emphasizing the early discoveries that led to its characterization. Recent Findings: Leukemia recognition began in the late 19th century with the advent of the microscope. Leeuwenhoek and Swammerdam described erythrocytes, while Lieutaud first observed globuli albicantes, later identified as lymphocytes by Hewson. Early case studies by Velpeau, Donné, Bennett, Craigie, Virchow, and Fuller suggested that leukocytosis could occur without infection. Virchow coined the term “leukemia,” while Bennett proposed “leucocythemia.” Neumann identified the bone marrow as the source of blood cells and leukemia, coining the term “myelogenous leukemia,” and Ehrlich classified leukemia into myeloid and lymphoid types. In 1914, Boveri linked chromosomal abnormalities to cancer, and in 1960, Nowell and Hungerford discovered the Philadelphia chromosome. The use of mustard gas in WWI led to the development of chemotherapy drugs like chlorambucil and busulfan. The Human Genome Project further advanced leukemia diagnosis and treatment. Summary: Leukemia, like many diseases, has evolved due to changes in causative factors such as viruses, bacteria, and genetic mutations, which have impacted its pathogenesis and treatment. It will undoubtedly continue to evolve, with new scientists working towards a cure for this devastating disease. ©The author ©Current Oncology Reports ©Springer Science and Business Media LLC.
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Los secretos de la cocina del Castillo de Tübingen: Friedrich Miescher y el descubrimiento de la nucleína, piedra angular del ADN
(Publicidad Permanyer, 2024)
En 1869, Friedrich Miescher, nacido en Basilea, Suiza, descubrió una sustancia rica en fósforo, hasta entonces desconocida, en los núcleos de las células del pus. Al realizar su investigación en un laboratorio instalado en la cocina del castillo medieval de Tübingen, en Alemania, y bajo la dirección del profesor Felix Hoppe-Seyler, Miescher se centró principalmente en la composición de los núcleos celulares. Obtuvo material nuclear de las células del pus de vendajes quirúrgicos proporcionados por un hospital cercano. En 1869, Miescher describió una molécula nuclear completamente nueva que, a diferencia de las proteínas, contenía grandes cantidades de fósforo. Llamó a esta sustancia “nucleína”, con lo que marcó la primera descripción del ADN. Miescher falleció mucho antes de que Watson, Crick, Wilkins y Franklin anunciaran, en 1953, el papel preciso que desempeñaba el ADN en las células. A través de su descubrimiento, Miescher sentó las bases para todas las investigaciones posteriores sobre el ADN. ©El autor. ©Gaceta Médica de México.
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Meduloepitelioma pigmentado maligno intraocular. Presentación de dos casos
(2009)
Soria-Céspedes, Danny
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Martínez-Madrigal, Fernando
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Méndez-Sashida, Pedro
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Intraocular medulloepithelioma is a rare embryonal tumour that occurs most often in the ciliary body, but may also arise from the iris, retina or optic nerve. We present two cases of pigmented malignant intraocular medulloepithelioma; one teratoid (with hyaline cartilage as a heterologous element), and one non-teratoid. Histochemistry showed the neoplastic cells synthesizing both an acidic substance that stained positive with alcian blue and melanin pigment positive for Fontana- Masson stain. Immunohistochemistry showed positive staining for markers of several lines of differentiation including neuroepithelial (S100 protein, synaptophysin), glial (GFAP), mesenchymal/muscle (vimentin, desmin), epithelial (cytokeratin AE1/3, EMA) and melanocytic (HMB-45, Melan-A). Intraocular medulloepithelioma is composed of multipotential cells capable of polyimmunophenotypic expression. © Revista Española de Patología
Scopus© Citations 2 37 2
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El profesor y la costurera: Un episodio de la vida de Jacob Henle
(2015)
Jacob Henle was a great German anatomist and one of the most important histologists of all times. One of the most commonly used eponymous terms in renal histology is the loop of Henle, but many other anatomical and pathological findings are associated with his name. During his stay in Zurich he fell in love with Elise Egolff who worked as a maid and seamstress in the house of one of his friends. No one could ever imagine how the wide social chasm that separated the servant-girl and the professor could be bridged. Henle arranged for his sister Marie to educate Elise and give her social polish. In a short time Elise was transformed into a lady of the world. A year and a half later Jacob and Elise were married. This episode inspired the novelist Auerbach to write the novel “The Professor’s Wife”, and the play “Pygmalion” by George B Shaw. (Gac Med Mex. 2015;151:819-27). © Gaceta Médica de México.
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Sarcoma histiocítico. Criterios diagnósticos histopatológicos e inmunohistoquímicos y sus diagnósticos diferenciales
(2011)
García-Gutiérrez, Mónica
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Histiocytic sarcoma (HS) is a rare malignant tumor, originating from bone marrow-derived myeloid stem cells, showing morphologic and immunophenotipic evidence of mature tissue histiocytes (macrophages). HS arises in lymph nodes and extranodal sites such as skin, soft tissues and particularly the gastrointestinal tract, often presenting with clinically advanced disease and pursuing and aggressive clinical course. The diagnosis of HS relies predominantly on the immunohistochemical features of the histiocytic lineage, and the exclusion of large cell lymphoma and other poorly differentiated large cell malignancies such as, carcinomas and melanomas.© Gaceta Mexicana de Oncología
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Linfoma de células B de la zona marginal extraganglionar del tejido linfoide asociado a mucosas (linfoma MALT). Evolución histórica y conceptos actuales
(2007)
Piña-Oviedo, Sergio
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Se han realizado avances importantes en el entendimiento del linfoma de la zona marginal, (linfoma MALT), desde la primera descripción en 1983 por Peter Isaacson y Dennis Wright. Los linfomas MALT son un subgrupo de neoplasias de bajo grado que representan entre el 7 y el 8 % de todos los linfomas B, que se originan en sitios extraganglionares y presentan características clínico-patológicas propias. Se mantienen localizados por largos periodos de tiempo y sólo ocasionalmente se diseminan a otros órganos. Rara vez se originan de un MALT normal y aparecen en el MALT adquirido en el curso de alteraciones inflamatorias crónicas como en el síndrome de Sjögren o la infección por Helicobacter pylori. La erradicación de H. pylori puede producir regresión clínica del linfoma en un 75 % de los casos. Histológicamente presenta células B neoplásicas centrocitoides, células monocitoides y lesiones linfoepiteliales. El aparato digestivo, particularmente el estómago, está afectado en las dos terceras partes de los casos. Sin embargo, puede presentarse en otros órganos como glándulas salivales, pulmón, tiroides, anexos oculares y piel. Estudios genéticos han identificado tres traslocaciones cromosómicas específicas que son: t(11:18)(q21;q21), t(1;14)(p22;q32), y t(14;18)(q32;q21). A pesar de que estas traslocaciones afectan diferentes genes, comparten una vía oncogénica común que afecta al NFκB. ©Gac Méd Méx Vol. 143 No. 3, 2007
Scopus© Citations 4 15 1
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Sarcoma de células dendríticas foliculares de localización ganglionar y extraganglionar. Estudio clinicopatoló gico e inmunohistoquímico de cinco casos
(Academia Mexicana de Cirugía, 2008)
Jorge-Buys, Diego Leonardo
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Lastra-Camacho, Gustavo
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Campos-Martínez, Jesús
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Romero-Guadarrama, Mónica
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Dendritic cells (DC) are an essential component of the nonlymphoid, nonphagocytic immunoaccessory reticulum cells of the peripheral lymphoid tissue. Follicular dendritic cells (FDC) are one type of DC in the lymphoid follicle associated with B lymphocytes. They play an important role in the capture and presentation of antigens, generation and regulation of immune complexes. FDC can be recognized histologically by their oval to triangular nucleus, delicate basophilic nuclear membrane, almost empty nucleoplasm, small but distinct central nucleolus, and indistinct cellular outline; some cells can be binucleated or multinucleated. Ultrastructurally, they possess delicate interwoven cell processes connected by desmosomes. Immunohistochemically, they can be highlighted by staining with CD21, CD35, R4/23, Ki-M4, CNA-42 and CD68 (Kp1). FDC sarcoma is rare. FDC sarcomas affected predominantly lymph nodes with occasional extranodal involvement. Many cases of FDC sarcomas are probably misdiagnosed as other tumors such as large cell lymphoma, sarcomatoid carcinomas, fusocellular sarcomas or melanomas. We present herein five cases of FDC sarcomas and discuss the salient clinical, pathological and immunohistochemical features of these tumors. © Cirugía y Cirujanos
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Diagnóstico del linfoma de la zona marginal (linfoma MALT) gástrico temprano, en biopsias endoscópicas. Informe de un caso que ilustra la utilidad de la inmunohistoquímica y el análisis molecular
(2008-07)
Piña-Oviedo, Sergio
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Fend, F.
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Kramerm M.
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Farca, A.
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MALT lymphomas are a subtype of low grade lymphomas that represent 7-8% of all B-cell lymphomas originated in extranodal sites. Nearly 50% of the cases present as primary gastric lymphomas. They arise from the acquired MALT developed dur- r ing the course of H. pylori chronic infection. Microscopically, the presence of lymphoid follicles with follicular colonization, marginal zone (`centrocytoid¿) cells and lymphoepithelial lesions is char- r acteristic. Histopathological diagnosis may result difficult in superficial endoscopic biopsies showing atypical lymphoid infiltrates. Using Wotherspoon criteria along with molecular analyses is useful in borderline lesions. We present the case of a 62 years old female with chronic gastritis. A small endoscopic biopsy was performed and the presence of a heterogeneous lymphoid infiltrate in the lamina propia was observed. Immunohistochemical profile showed focal co expression of CD20 and CD43 and kappa light chain restriction. The diag- g nosis of an atypical lymphoid infiltrate highly suspicious of MALT lymphoma was established. PCR molecular analysis corroborated the monoclonal pattern of the lymphoid cells and the diagnosis of lymphoma. Immunohistochemical and molecular analyses in cases of lymphoid infiltrates suspicious of malignancy (Wotherspoon 3 and 4) will aid in the adequate diagnosis between chronic gastritis and MALT lymphoma, which is crucial for prognosis, treatment and patient¿s outcome.©Revista de Gastroenterología de México
Scopus© Citations 2 14 1
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Comparación inmunohistoquímica entre la GCDFP-15 y los receptores para estrógenos y progesterona en el diagnóstico de carcinoma metastásico de la mama
(2012-05)
Villarroel Salinas, Jaime
;
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Soria Céspedes, Danny
Antecedentes: en el estudio de tumores de sitio primario no conocido en mujeres, una consideración frecuente es carcinoma mamario, porque puede presentarse como metástasis. Objetivo: describir y comparar el patrón inmunohistoquímico de los receptores hormonales (receptor de estrógenos [RE] y receptor de progesterona [RP]) y GCDFP-15 en carcinoma mamario metastásico en ganglio linfático según el grado histológico. Métodos: estudio retrospectivo donde se analizan 30 casos de carcinoma mamario con metástasis ganglionar, divididos en tres grupos: grado I (bien diferenciado), grado II (moderadamente diferenciado) y grado III (poco diferenciado). Se utilizaron tres anticuerpos (RE, RP y GCDFP-15) en el ganglio linfático y se comparó su expresión según el grado histológico. Resultados: en ganglios linfáticos con metástasis de carcinoma mamario grado I los receptores hormonales fueron positivos en el 100% y GCDFP-15 en el 80%. En grado II, el RE y el RP fueron positivos en el 90 y 40%, respectivamente, y GCDFP-15 en el 80%. En grado III, el RE y RP fueron positivos en el 30 y 50%, respectivamente, y GCDFP-15 en el 60%. ©Gaceta Médica de México
Scopus© Citations 3 8 2

Ortíz Hidalgo, Carlos Federico

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