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    Sarcoma histiocítico. Criterios diagnósticos histopatológicos e inmunohistoquímicos y sus diagnósticos diferenciales
    (2011)
    García-Gutiérrez, Mónica
    ;
    Histiocytic sarcoma (HS) is a rare malignant tumor, originating from bone marrow-derived myeloid stem cells, showing morphologic and immunophenotipic evidence of mature tissue histiocytes (macrophages). HS arises in lymph nodes and extranodal sites such as skin, soft tissues and particularly the gastrointestinal tract, often presenting with clinically advanced disease and pursuing and aggressive clinical course. The diagnosis of HS relies predominantly on the immunohistochemical features of the histiocytic lineage, and the exclusion of large cell lymphoma and other poorly differentiated large cell malignancies such as, carcinomas and melanomas.© Gaceta Mexicana de Oncología
      1  8
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    Mujer de 33 años de edad con leve dolor toracoabdominal derecho de seis años de evolución, súbitamente agudizado
    (2011)
    Cárdenas-Escudero, Mara A.
    ;
    Shuchleib-Chaba, Samuel
    ;
    Muruchi-Garrón, Germán Walter
    ;
    León-Bojorge, Beatriz de
    ;
    We present a case of a benign hybrid nerve sheath tumor showing features of both cellular schwannoma and perineurioma. The patient was a 33 year-old female who presented with a 6 month history of pain in the thorax-lumbar region. Axial CT and MIR images showed and homogeneously enhancing solid oval mass involving the left paravertebra region in contact with the vertebral foramina T9-T11. Morphologically the tumor presented a well formed capsule and showed a uniform highly spindle cell proliferation. The spindle cells were arranged in whorls and intersecting fascicles with focal intervening sclerosis and relatively uniform cellularity with a prominent perivascular lymphocytic infiltrate. No cytological atypia, necrosis or mitoses were present. A second cell component was present composed of spindle-shaped cells with inconspicuous bipolar, pale, eosinophilic cytoplasm with oval nuclei. By immunohistochemistry there was a diffuse staining for S-100, and the elongated bipolar cells were EMA, Glut-1 and Claudin-1. To our knowledge this is the first reported case of a hybrid cellular schwannoma/perineurioma. ©Gaceta Médica de México
      2  9
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    El profesor y la costurera: Un episodio de la vida de Jacob Henle
    Jacob Henle was a great German anatomist and one of the most important histologists of all times. One of the most commonly used eponymous terms in renal histology is the loop of Henle, but many other anatomical and pathological findings are associated with his name. During his stay in Zurich he fell in love with Elise Egolff who worked as a maid and seamstress in the house of one of his friends. No one could ever imagine how the wide social chasm that separated the servant-girl and the professor could be bridged. Henle arranged for his sister Marie to educate Elise and give her social polish. In a short time Elise was transformed into a lady of the world. A year and a half later Jacob and Elise were married. This episode inspired the novelist Auerbach to write the novel “The Professor’s Wife”, and the play “Pygmalion” by George B Shaw. (Gac Med Mex. 2015;151:819-27). © Gaceta Médica de México.
      2  9
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    Small-Cell Plasmacytoma With Prominent Myxoid Stroma Mimicking a Soft-Tissue Neoplasm
    (2009)
    Lara-Torres, César Octavio
    ;
    Gómez-Plata, Eduardo
    ;
    In the majority of cases, histological diagnosis of plasma cell tumor can be made without difficulty; however, a proportion of them can represent a diagnostic challenge due to the wide spectrum of phenotypes that neoplastic plasma cells may exhibit. Numerous cytological and architectural variants have been well documented. Cytological, plasma cell tumors may show small, cleaved, multilobated, monocytoid, pleomorphic, histiocytoid, oncocytic, or clear cells. © International Journal of Surgical Pathology
      2Scopus© Citations 2  12
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    Hematoxylin: Mesoamerica's Gift to Histopathology. Palo de Campeche (Logwood Tree), Pirates' Most Desired Treasure, and Irreplaceable Tissue Stain
    (2019) ;
    Pina-Oviedo, Sergio
    Hematoxylin is a basic dye derived from the heartwood of Palo de Campeche ( Haematoxylum campechianum), the logwood tree native to Mexico and Central America. Haematoxylum means "bloodwood" in reference to its dark-red heartwood and campechianum refers to its site of origin, the coastal city of Campeche on the Yucatan Peninsula, Mexico. Hematoxylin is colorless but it turns into the color dye hematein after oxidation (ripening). The dyeing property of logwood was well-known to the natives of the Yucatan Peninsula before the arrival of the Spaniards who brought it to Europe shortly after the discovery of the Americas. An important trade soon developed related to growing and preparing hematoxylin for dyeing fabrics. Pirates discovered that one shipload of logwood was equivalent to a year's value from any other cargo, and by 1563, more than 400 pirate vessels wandered the Atlantic Ocean and attacked Spanish galleons transporting gold, silver, and logwood from the Americas to Europe. Hematoxylin and eosin is a staining method that dates back to the late 19th century. In 1865 and 1891, Böhmer and Meyer, respectively, first used hematoxylin in combination with a mordant (alum). Later, with the use of anilines by Ehrlich, the repertoire of stains expanded rapidly resulting in the microscopic descriptions of multiple diseases that were defined by their stainable features. Today hematoxylin, along with eosin, remains the most popular stain in histology.©International Journal of Surgical Pathology
      2  7Scopus© Citations 34
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    Enfermedad de Castleman. Análisis histopatológico e inmunohistoquímico de treinta y nueve casos
    (2017)
    Brisa Sevilla-Lizcano, Diana
    ;
    Frias-Soria, Christian Lizette
    ;
    Introduction: Castleman disease (CD) is a rare lymphoproliferative that comprises two distinct clinical subtypes (unicentric and multicentric) and has two basic histopathology patterns that are hyaline-vascular (HV) and plasma-cell (PC) type. Some cases of multicentric PC disease are associated with HHV-8 infection. Objective: To present the histopathologic and immunohistochemical characteristics of 39 cases of CD. Methods: A review of cases with the diagnosis CD from the files of the Department of Pathology of the ABC Medical Centre in Mexico City was performed. Thirty-nine cases of CD were identified, and a detailed paraffin immunophenotypic study of 9 of them was completed using desmin, cytokeratin OSCAR (CO) and Epidermal growth factor receptor (EGFR), to evaluate the dendritic cell population. ©Gaceta Médica de México.
    Scopus© Citations 7  2  10
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    Immunohistochemistry in Historical Perspective: Knowing the Past to Understand the Present
    Immunohistochemistry is an extraordinary and extensively used technique whereby antibodies are used to detect antigens in cells within a tissue section. It has numerous applications in medicine, particularly in cancer diagnosis. It was Albert Hewett Coons, Hugh J Creech, Norman Jones, and Ernst Berliner who conceptualized and first implemented the procedure of immunofluorescence in 1941. They used fluorescein isothiocyanate (FITC)-labelled antibodies to localize pneumococcal antigens in infected tissues. Since then, with improvement and development of protein conjugation, enzyme labels have been introduced, such as peroxidase and alkaline phosphatase. The history of immunohistochemistry (IHC) combines physiology, immunology, biochemistry, and the work of various Nobel Prize laureates. From von Behring who was awarded de first Nobel Prize in 1901 for his work on serum therapy to the 1984 Nobel Prize for the discovery of monoclonal antibodies by Milstein, Kohler, and Jerne, IHC is a story of cooperation and collaboration which led to the development of this magnificent technique that is used daily in anatomical pathology laboratories worldwide. © Springer Nature.
      1  18Scopus© Citations 30
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    Tumor rabdoide/teratoide atípico. Presentación de tres casos y revisión de la literatura
    (2001)
    Cuesta Mejías, Teresa Cristina
    ;
    León Bojorge, Beatriz de
    ;
    Rivas Hernández, Angélica
    ;
    Martínez Madrigal, Fernando
    ;
    Cuevas, Francisco
    Introducción: El tumor rabdoide/teratoide atípico (TR/TA) del sistema nervioso central (SNC) ha emergido de una variante de meduloblastoma a una entidad clinicopatológica distintiva, durante la última década. Esto tiene importancia más que nosológica, ya que la supervivencia de cinco años prevista en los meduloblastomas es considerablemente mejor que la de 11 meses (promedio) mostrada por los TR/TA. Objetivo: Describir las principales características clinicopatológicas de una entidad recientemente reconocida, haciendo énfasis en su polimorfismo y diagnóstico diferencial. Pacientes y métodos: Se presenta el aspecto clínico, radiológico, citohistopatológico e inmunohistoquímico de tres TR/TA diagnosticados en el Hospital A.B.C. de la Ciudad de México. ©Revista de Neurología
      1  9Scopus© Citations 4
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    Foliculitis pseudolinfomatosa. Estudio clinicopatológico e inmunohistoquímico de 19 casos y su diagnóstico diferencial
    (Academia Nacional de Medicina de México A.C., 2014)
    Granados-López, Sandy Lucero
    ;
    Tousaint-Caire, Sonia
    ;
    Moreno-Collado, Clemente
    ;
    Brindis-Zabaleta, Mauricio
    ;
    Introducción: La foliculitis pseudolinfomatosa (FPL) es una forma de hiperplasia linfoide cutánea (HLC) rara, que se presenta más frecuentemente en la región facial en forma de lesión nodular. Material y métodos: Presentamos el estudio clinicopatológico e inmunohistoquímico de 19 casos de FPL. Resultados: Los pacientes eran 11 mujeres y 8 hombres (edad promedio de 44.9 años; rango de 9-77 años). Todos los casos eran de lesiones solitarias, a excepción de uno que presentó lesiones múltiples. Histológicamente los infiltrados linfoide fueron difusos o nodulares, con hiperplasia y dilatación de los folículos pilosos y ocasionalmente crecimiento de las unidades ecrinas con aclaramiento nuclear. Por inmunohistoquímica, tres casos mostraron predominio de células B, ocho casos predominio de células B con numerosas células T, seis casos predomino de células T con numerosas células B y dos casos predominantemente de células T. Todos los casos mostraron numerosas células dendríticas perifoliculares positivas al S-100 y CD1a. Discusión: La FPL es una forma de hiperplasia cutánea rara que puede semejar linfoma cutáneo. Tiene características clínicas y patológicas propias, y muestra abundantes células dendríticas positivas a la S-100/CD1a, con activación y dilatación de la unidad pilosebácea. La FPL se resuelve por escisión completa o puede presentar regresión espontánea. ©Gaceta Médica de México.
      2  8
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    Diffuse Membranous Immunoreactivity of CD56 and Paranuclear Dot-like Staining Pattern of Cytokeratins AE1/3, CAM5.2, and OSCAR in Undifferentiated (Embryonal) Sarcoma of the Liver
    (2010)
    Pérez-Gómez, Rosa María
    ;
    Soria-Céspedes, Danny
    ;
    León-Bojorge, Beatriz de
    ;
    To the editor: Undifferenced (embryonal) sarcoma of the liver (UESL) is an uncommon, rapidly growing malignant spindle cell tumor that usually occurs in children and young adults, as characterized by Stocker and Ishak in 1978. © Applied Immunohistochemistry & Molecular Morphology
      2  18Scopus© Citations 11