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    Pathological and Immunohistochemical Features of Malignant Peripheral Nerve Sheath Tumor With Heterologous Rhabdomy Oblastic Differentiation (Malignant Triton Tumor) in the Context of the Malignant Peripheral Nerve Sheath Tumor Spectrum
    (SAGE Publications, 2025-12-17)
    Luis Felipe Arias-Ruiz
    ;
    <jats:p>Malignant peripheral nerve sheath tumors (MPNST) are aggressive sarcomas arising from Schwann cells or neurofibromas, comprising ∼10% of soft tissue sarcomas. Found in 8% to 13% of neurofibromatosis type 1 patients, they typically show spindle cells expressing S100 and SOX10. Some display heterologous differentiation (bone, cartilage, vessels, or glands). When rhabdomyosarcomatous features are present, they are called malignant peripheral nerve heath tumor with heterologous rhabdomyoblastic differentiation (malignant triton tumors), which are more prone to recurrence, metastasis, and worse outcomes. Epithelial differentiation does not affect prognosis. Despite advances in understanding MPNST biology, many pathophysiological mechanisms remain unclear. This review highlights their histopathology, focusing on malignant triton tumor.</jats:p>
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    History of Leukemia, Revisited
    (Springer Science and Business Media LLC, 2025)
    Purpose of the Review: Provide a general historical overview of leukemia, emphasizing the early discoveries that led to its characterization. Recent Findings: Leukemia recognition began in the late 19th century with the advent of the microscope. Leeuwenhoek and Swammerdam described erythrocytes, while Lieutaud first observed globuli albicantes, later identified as lymphocytes by Hewson. Early case studies by Velpeau, Donné, Bennett, Craigie, Virchow, and Fuller suggested that leukocytosis could occur without infection. Virchow coined the term “leukemia,” while Bennett proposed “leucocythemia.” Neumann identified the bone marrow as the source of blood cells and leukemia, coining the term “myelogenous leukemia,” and Ehrlich classified leukemia into myeloid and lymphoid types. In 1914, Boveri linked chromosomal abnormalities to cancer, and in 1960, Nowell and Hungerford discovered the Philadelphia chromosome. The use of mustard gas in WWI led to the development of chemotherapy drugs like chlorambucil and busulfan. The Human Genome Project further advanced leukemia diagnosis and treatment. Summary: Leukemia, like many diseases, has evolved due to changes in causative factors such as viruses, bacteria, and genetic mutations, which have impacted its pathogenesis and treatment. It will undoubtedly continue to evolve, with new scientists working towards a cure for this devastating disease. ©The author ©Current Oncology Reports ©Springer Science and Business Media LLC.
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    Linfoma de células B de la zona marginal extraganglionar del tejido linfoide asociado a mucosas (linfoma MALT). Evolución histórica y conceptos actuales
    (2007)
    Piña-Oviedo, Sergio
    ;
    Se han realizado avances importantes en el entendimiento del linfoma de la zona marginal, (linfoma MALT), desde la primera descripción en 1983 por Peter Isaacson y Dennis Wright. Los linfomas MALT son un subgrupo de neoplasias de bajo grado que representan entre el 7 y el 8 % de todos los linfomas B, que se originan en sitios extraganglionares y presentan características clínico-patológicas propias. Se mantienen localizados por largos periodos de tiempo y sólo ocasionalmente se diseminan a otros órganos. Rara vez se originan de un MALT normal y aparecen en el MALT adquirido en el curso de alteraciones inflamatorias crónicas como en el síndrome de Sjögren o la infección por Helicobacter pylori. La erradicación de H. pylori puede producir regresión clínica del linfoma en un 75 % de los casos. Histológicamente presenta células B neoplásicas centrocitoides, células monocitoides y lesiones linfoepiteliales. El aparato digestivo, particularmente el estómago, está afectado en las dos terceras partes de los casos. Sin embargo, puede presentarse en otros órganos como glándulas salivales, pulmón, tiroides, anexos oculares y piel. Estudios genéticos han identificado tres traslocaciones cromosómicas específicas que son: t(11:18)(q21;q21), t(1;14)(p22;q32), y t(14;18)(q32;q21). A pesar de que estas traslocaciones afectan diferentes genes, comparten una vía oncogénica común que afecta al NFκB. ©Gac Méd Méx Vol. 143 No. 3, 2007
    Scopus© Citations 4  15  1
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    Sarcoma histiocítico. Criterios diagnósticos histopatológicos e inmunohistoquímicos y sus diagnósticos diferenciales
    (2011)
    García-Gutiérrez, Mónica
    ;
    Histiocytic sarcoma (HS) is a rare malignant tumor, originating from bone marrow-derived myeloid stem cells, showing morphologic and immunophenotipic evidence of mature tissue histiocytes (macrophages). HS arises in lymph nodes and extranodal sites such as skin, soft tissues and particularly the gastrointestinal tract, often presenting with clinically advanced disease and pursuing and aggressive clinical course. The diagnosis of HS relies predominantly on the immunohistochemical features of the histiocytic lineage, and the exclusion of large cell lymphoma and other poorly differentiated large cell malignancies such as, carcinomas and melanomas.© Gaceta Mexicana de Oncología
      11  1
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    El profesor y la costurera: Un episodio de la vida de Jacob Henle
    (2015)
    Jacob Henle was a great German anatomist and one of the most important histologists of all times. One of the most commonly used eponymous terms in renal histology is the loop of Henle, but many other anatomical and pathological findings are associated with his name. During his stay in Zurich he fell in love with Elise Egolff who worked as a maid and seamstress in the house of one of his friends. No one could ever imagine how the wide social chasm that separated the servant-girl and the professor could be bridged. Henle arranged for his sister Marie to educate Elise and give her social polish. In a short time Elise was transformed into a lady of the world. A year and a half later Jacob and Elise were married. This episode inspired the novelist Auerbach to write the novel “The Professor’s Wife”, and the play “Pygmalion” by George B Shaw. (Gac Med Mex. 2015;151:819-27). © Gaceta Médica de México.
      12  2
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    Tumor de Küttner (sialoadenitis crónica esclerosante). Estudio clinicopatológico e inmunohistoquímico de 8 casos de una entidad poco reconocida
    (2007)
    Martínez Consuegra, Nayeli
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    Baquera Heredia, Javier
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    Sánchez Cisneros, Rodolfo
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    Márquez Rocha, María Luisa
    ;
    Objective: To present the clinical-pathological characteristics of Küttner's tumour (KT) or chronic sclerosing sialadenitis. Material and method: We studied 8 cases of KT that were graduated histologically according to the Seifert grading system. An immunohistochemistry panel including CD20, CD3, and keratin AE1-3 was performed. ©Acta Otorrinolaringológica Española
    Scopus© Citations 3  11  1
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    Immunohistochemical Expression of Luteinizing Hormone Receptor in Solid Pseudopapillary Tumor of the Pancreas
    (2014)
    Domínguez-Rosado, Ismael
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    Chan, Carlos
    ;
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    Chablé-Montero, Freddy
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    Uscanga, Luis F.
    To the editor: Solid pseudopapillary tumor (SPT) of the pancreas is an uncommon neoplasm usually prevalent in young women with low malignant prognosis. Little has been studied regarding its high frequency in reproductive-age women. Despite the immunohistochemical expression of progesterone and a estrogen receptors, gonadotropin receptor expression has never been studied. The aim of this work is to describe whether luteinizing hormone (LH) receptor is expressed in SPTs of the pancreas. © Pancreas
    Scopus© Citations 2  10  2
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    Traumatic and compressive lesions of peripheral nerves
    (2014)
    ;
    Weller, Roy O.
    Injuries to peripheral nerves range from acute and chronic compression, to entrapment and traumatic transection. Clinically, traumatic lesions present with loss of sensation and muscle power; electrophysiology is used to localize lesions and to determine their nature and extent. Pathology of traumatic lesions ranges from myelin displacement and demyelination in compressive lesions to complete transection of nerves associated with penetrating injuries and fractures. Entrapment of peripheral nerves occurs in bony or muscle and ligamentous tunnels, particularly in older age groups with damage to nerves from stretching, restriction of movement and deprivation of blood supply. Focal lesions that result from trauma to peripheral nerves described here include traumatic neuromas, Morton's neuroma, reactive perineurial hyperplasia and focal hypertrophic neuropathy. Copyright © 2014 International Society of Neuropathology.
      12  1
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    Sarcoma de células dendríticas foliculares de localización ganglionar y extraganglionar. Estudio clinicopatoló gico e inmunohistoquímico de cinco casos
    (Academia Mexicana de Cirugía, 2008)
    Jorge-Buys, Diego Leonardo
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    Lastra-Camacho, Gustavo
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    Campos-Martínez, Jesús
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    Romero-Guadarrama, Mónica
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    Dendritic cells (DC) are an essential component of the nonlymphoid, nonphagocytic immunoaccessory reticulum cells of the peripheral lymphoid tissue. Follicular dendritic cells (FDC) are one type of DC in the lymphoid follicle associated with B lymphocytes. They play an important role in the capture and presentation of antigens, generation and regulation of immune complexes. FDC can be recognized histologically by their oval to triangular nucleus, delicate basophilic nuclear membrane, almost empty nucleoplasm, small but distinct central nucleolus, and indistinct cellular outline; some cells can be binucleated or multinucleated. Ultrastructurally, they possess delicate interwoven cell processes connected by desmosomes. Immunohistochemically, they can be highlighted by staining with CD21, CD35, R4/23, Ki-M4, CNA-42 and CD68 (Kp1). FDC sarcoma is rare. FDC sarcomas affected predominantly lymph nodes with occasional extranodal involvement. Many cases of FDC sarcomas are probably misdiagnosed as other tumors such as large cell lymphoma, sarcomatoid carcinomas, fusocellular sarcomas or melanomas. We present herein five cases of FDC sarcomas and discuss the salient clinical, pathological and immunohistochemical features of these tumors. © Cirugía y Cirujanos
      26  1
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    Primary Adamantinoma of the Rib. Unusual Presentation for a Bone Neoplasm of Uncertain Origin
    (2008)
    Piña-Oviedo, Sergio
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    Valle, Luis del
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    Padilla-Longoria, Rafael
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    Mendoza-Ramón, Hilda
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    Adamantinomas are rare, low-grade malignant intra-osseous tumors composed of epithelial and mesenchymal elements, which show a marked predilection for the tibia and fibula of young adult male patients. Although cases of adamantinoma located to the axial skeleton have been reported either as recurrent or metastatic disease, only two cases of primary adamantinoma located to the thoracic wall have been previously described. In this study we present the clinical, radiological and histopathological features of a 24-year-old male with a slow growing, solid-cystic, painful mass, located to the right 11th rib, which was morphological and immunohistochemically diagnosed as a primary classic adamantinoma. Radiological studies showed a multiloculated lesion with a solid component. The patient underwent a whole surgical resection of the lesion. Histologically, multiple foci of epithelial cells with basaloid and squamous components were found intermixed within a fibrous stromal tissue. Immunohistochemical analysis demonstrated expression of cytokeratins, EMA, vimentin and other epithelial markers. Primary affection of the rib is an unusual feature of classic adamantinomas. ©Pathology & Oncology Research
    Scopus© Citations 6  10  1