Hernández Gutiérrez, Salomón

Main Affiliation

Facultad de Ciencias de la Salud - CampCM

Preferred name

Official Name

Hernández Gutiérrez, Salomón

ORCID

0000-0001-7923-0359

Researcher ID

DVV-7932-2022

Scopus Author ID

15739969000

Now showing 1 - 10 of 21

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Ibervillea sonorae (S. Watson) Green a potential resource of bioactive compounds: Systematic analysis of a Mexican plant used in traditional medicine
(Elsevier, 2025)
Angulo Molina, Aracely
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Cristofaro, Valeria di
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Pieles, Uwe
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López Romero, Julio César
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Vidal Gutiérrez, Max
Ibervillea sonorae (S. Watson) Green (Cucurbitaceae) is a tuber succulent known as “wareke,” which grows in dry desert landscapes in northwestern Mexico and the southwestern United States. Indigenous tribes use I. sonorae as a remedy against cancer, inflammation, rheumatism, skin infections, and diabetes. The great popularity of wareke in traditional medicine has motivated various working groups to investigate its pharmacological properties. The antiproliferative, antitumoral, antifungal, hypoglycemic, antiinflammatory, antioxidant, and antimicrobial potential of this plant has been established. Chemical studies showed that I. sonorae is a potential resource of bioactive compounds, cucurbitacin-type triterpenoids, and phytosterols, the main secondary metabolites. The objective of this chapter is to systematically analyze the phytochemical knowledge of the plant (isolated and identified compounds), describe the biological activities of different extracts, isolated ingredients, and phytopreparations, and discuss their possible applications. ©The authors © 2025 Elsevier Inc.
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Células madre: buscando marcadores de superficie celular que predispongan compromiso de diferenciación cardiaca
(2018)
Lara Martínez, Luis Andrés
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Gutiérrez Villegas, Ingrid
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Arenas Luna, Victor Manuel
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Hernández Gutiérrez, Salomón
Actualmente las enfermedades cardiovasculares se han convertido en un serio problema para los sistemas de salud de todo el mundo, ya que son la principal causa de muerte y representan una enorme carga económica. Este problema ha sido abordado con diferentes estrategias, entre ellas con la ayuda de terapia celular, aunque sin resultados contundentes. Durante más de 20 años, se ha utilizado una gran variedad de células madre en diferentes modelos de infarto del miocardio. El uso de células madre cardiacas (CSC) parece ser la mejor opción, pero la inaccesibilidad y la escasez de estas células hacen que su uso sea muy limitado. Además, existe un riesgo elevado pues tienen que obtenerse directamente del corazón del paciente. A diferencia de las CSC, las células madre adultas derivadas de médula ósea o tejido adiposo, entre otras, representan una opción atractiva debido a su fácil accesibilidad y abundancia, pero sobre todo a la probable existencia de progenitores cardiacos entre sus diferentes subpoblaciones. En esta revisión hacemos un análisis de los marcadores de superficie presentes en CSC en comparación con otras células madre adultas, y sugerimos la preexistencia de células que comparten marcadores de superficie específicos con CSC, la presencia de un inmunofenotipo predecible, aunque en proporciones bajas, pero con un potencial de diferenciación cardiaca similar a las CSC, lo cual podría aumentar su valor terapéutico. Este estudio revela las nuevas perspectivas con respecto a la presencia de dichos marcadores, los cuales comprometerían algunas de estas subpoblaciones a diferenciarse a tejido cardiaco.
Scopus© Citations 2 36 1
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Increased CD47 and MHC Class I Inhibitory Signals Expression in Senescent CD1 Primary Mouse Lung Fibroblasts
(2021)
Hernández-Mercado, Elisa
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Prieto-Chávez, Jessica Lakshmi
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Arriaga-Pizano, Lourdes Andrea
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Hernández Gutiérrez, Salomón
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Mendlovic, Fela
Cellular senescence is more than a proliferative arrest in response to various stimuli. Senescent cells (SC) participate in several physiological processes, and their adequate removal is essential to maintain tissue and organism homeostasis. However, SC accumulation in aging and age-related diseases alters the tissue microenvironment leading to deterioration. The immune system clears the SC, but the specific scenarios and mechanisms related to recognizing and eliminating them are unknown. Hence, we aimed to evaluate the existence of three regulatory signals of phagocytic function, CD47, major histocompatibility complex class I (MHC-I), and calreticulin, present in the membrane of SC. Therefore, primary fibroblasts were isolated from CD1 female mice lungs, and stress-induced premature senescence (SIPS) was induced with hydrogen peroxide. Replicative senescence (RS) was used as a second senescent model. Our results revealed a considerable increment of CD47 and MHC-I in RS and SIPS fibroblasts. At the same time, no significant changes were found in calreticulin, suggesting that those signals might be associated with evading immune system recognition and thus averting senescent cells clearance.
Scopus© Citations 5 15 2
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Terapia celular y regeneración cardiaca. ¿Dónde estamos?
(2012)
Lara-Martínez, Luis Andrés
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Navarro Betancourt, Refugio
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Hernández Gutiérrez, Salomón
La terapia celular es un recurso prometedor para el tratamiento de la cardiopatía isquémica; mediante un procedimiento como la infusión directa o intravascular de células troncales al tejido dañado, es posible restituir la capacidad funcional del corazón. A pesar del éxito de los ensayos en animales, en humanos no se han obtenido los resultados esperados; además, se presenta una serie de limitantes éticas y prácticas que ponen en duda los resultados. Se ha comprobado que la terapia con células troncales mejora las propiedades electromecánicas del tejido cardiaco como tal; sin embargo, el beneficio funcional aún es poco convincente, pero no desalentador. La realización de ensayos clínicos más grandes y el perfeccionamiento de técnicas de seguimiento no invasivas son necesarios para evaluar de manera integral el beneficio de la terapia celular. Por otra parte, el problema de la supervivencia de las células injertadas es un conflicto relevante, lo que hace que la eficiencia de las células a transferir sea variable y generalmente baja; esto es causado principalmente por tres procesos: apoptosis, isquemia e inflamación. Hasta ahora, el mecanismo más prometedor para incrementar la viabilidad del injerto es la sobreexpresión de proteínas antiapoptóticas. Sin duda, el principal desafío para la terapia celular será determinar la estirpe más adecuada para el tratamiento. En esta revisión se describen los principales tipos de células que a la fecha han sido propuestas para la regeneración cardiaca: las células troncales embrionarias, las células pluripotentes inducidas, las células derivadas de médula ósea, los mioblastos esqueléticos y las células de tejido adiposo, entre otras.
14 1
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El papel del factor de transcripción NF-κB en la célula cardíaca
(2005)
Hernández Gutiérrez, Salomón
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Rojas del Castillo, Emilio
The signaling pathways that control the life-death switch of a cell are a prime interest in Modern Biology. To this respect, NF-κB has emerged as a decisive transcription factor in the cell’s response to apoptotic challenge and its effects on apoptosis have far-reaching consequences for normal development and/or homeostasis in many cells and tissues, including the immune system, hair follicles, and epidermal appendages, the liver, and nervous system. In this review we analyze the pivotal role of the transcription factor NF-κB in the normal functioning of the cardiac cell and its implication on some of the most frequent cardiac pathologies, such as ischemia-reperfusion injury, ischemic precondition, hypertrophy, atherosclerosis and cardiac arrest. While NF-κB is commonly found to be cytoprotective, there are a number of instances where it is proapoptotic depending on the inducing stimulus and the cell context. Significant progress has been made in understanding its mode of action and its interplay with other key factors. These studies identified many anti- and pro-apoptotic NFκB regulated genes that mediate its activity, these important new insights fuel hope that novel approaches will be developed to control the effects of NF-κB in cardiac pathologies.
4 2
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Pre-Conditioning with CDP-Choline Attenuates Oxidative Stress-Induced Cardiac Myocyte Death in a Hypoxia/Reperfusion Model
(2014)
González-Pacheco, Héctor
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Méndez-Domínguez, Aurelio
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Hernández Gutiérrez, Salomón
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López-Marure, Rebeca
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Vazquez-Mellado, Maria J.
Background: CDP-choline is a key intermediate in the biosynthesis of phosphatidylcholine, which is an essential component of cellular membranes, and a cell signalling mediator. CDP-choline has been used for the treatment of cerebral ischaemia, showing beneficial effects. However, its potential benefit for the treatment of myocardial ischaemia has not been explored yet. Aim: In the present work, we aimed to evaluate the potential use of CDP-choline as a cardioprotector in an in vitro model of ischaemia/reperfusion injury. Methods: Neonatal rat cardiac myocytes were isolated and subjected to hypoxia/reperfusion using the coverslip hypoxia model. To evaluate the effect of CDP-choline on oxidative stress-induced reperfusion injury, the cells were incubated with H₂O₂ during reperfusion. The effect of CDP-choline pre- and postconditioning was evaluated using the cell viability MTT assay, and the proportion of apoptotic and necrotic cells was analyzed using the Annexin V determination by flow cytometry.
Scopus© Citations 8 10 2
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Standardized phytopreparations and cucurbitacin IIb from Ibervillea sonorae (S. Watson) greene induce apoptosis in cervical cancer cells by Nrf2 inhibition
(2022)
Vidal-Gutiérrez, Max
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Torres-Moreno, Heriberto
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Arenas Luna, Victor Manuel
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Loredo Mendoza, María Lilia
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Velazquez, Carlos
Ethnopharmacology relevance: Ibervillea sonorae (S. Watson) Greene is a plant from northwestern Mexico, known as “Wereke” or “Guareque”, used by the Mayo ethnic group to treat diabetes and cancer. Cucurbitacin IIb (CIIb), isolated from I. sonorae has apoptotic and antitumor activity in a model of cervical cancer with the HeLa cell line. One pathway affected by cucurbitacins is Nrf2, a glutathione transferase (GST) transcription factor, important in the regulation of mitochondrial oxidative stress (MOS). A signal of MOS is the change in the mitochondrial membrane potential (ΔΨm), which has been detected in HeLa in the presence of CIIb. Fito-Ison-EtOH (Etanison) and Fito-Ison-EtOAc (Acetison) are phytopreparations from I. sonorae standardized according to their CIIb content (6.7 mg/g and 18.4 mg/g of CIIb, respectively). Etanison and Acetison have been reported to induce morphological changes in HeLa like those induced by CIIb. Aim of the study: To evaluate the apoptotic and Nrf2 inhibition activity of the phytopreparations Acetison and Etanison from Ibervillea Sonorae in the HeLa cervical cancer cell line. Materials and methods : Antiproliferative activity was evaluated by the MTT method at 24, 48, and 72 h. For Acetison and Etanison, serial concentrations from 6.25 μg/mL to 100 μg/mL were tested, and for CIIb from 1.56 μg/mL to 50 μg/mL. The expression of Nrf2, caspase 3, and caspase 9 was evaluated by western blot, using concentrations of 30 μg/mL for Acetison, 50 μg/mL for Etanison, and 15 μg/mL for CIIb. Cisplatin was used as a positive control.
Scopus© Citations 5 65 1
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Evaluating the biological risk of functionalized multiwalled carbon nanotubes and functionalized oxygen-doped multiwalled carbon nanotubes as possible toxic, carcinogenic, and embryotoxic agents
(2017)
Lara-Martínez, Luis Andres
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Massó, Felipe A.
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Palacios, Eduardo
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García-Pelaéz, Isabel
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Contreras-Ramos, Alejandra
Carbon nanotubes (CNTs) have been a focus of attention due to their possible applications in medicine, by serving as scaffolds for cell growth and proliferation and improving mesenchymal cell transplantation and engraftment. The emphasis on the benefits of CNTs has been offset by the ample debate on the safety of nanotechnologies. In this study, we determine whether functionalized multiwalled CNTs (fMWCNTs) and functionalized oxygen-doped multiwalled CNTs (fCOxs) have toxic effects on rat mesenchymal stem cells (MSCs) in vitro by analyzing morphology and cell proliferation and, using in vivo models, whether they are able to transform MSCs in cancer cells or induce embryotoxicity. Our results demonstrate that there are statistically significant differences in cell proliferation and the cell cycle of MSCs in culture. We identified dramatic changes in cells that were treated with fMWCNTs. Our evaluation of the transformation to cancer cells and cytotoxicity process showed little effect. However, we found a severe embryotoxicity in chicken embryos that were treated with fMWCNTs, while fCOxs seem to exert cardioembryotoxicity and a discrete teratogenicity. Furthermore, it seems that the time of contact plays an important role during cell transformation and embryotoxicity. A single contact with fMWCNTs is not sufficient to transform cells in a short time; an exposure of fMWCNTs for 2 weeks led to cell transformation risk and cardioembryotoxicity effects.
Scopus© Citations 9 20 1
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Nuclear Transcription Factor Kappa B Downregulation Reduces Chemoresistance in Bone Marrow-derived Cells Through P-glycoprotein Modulation
(2016)
Loaiza, Brenda
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Hernández Gutiérrez, Salomón
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Montesinos, Juan José
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Valverde, Mahara
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Rojas, Emilio
Nuclear transcription factor kappa B (NF-κB) is associated with many types of refractory cancer. However, despite multiple strategies to treat cancer and novel target drugs, multidrug resistance still causes relapses. The best-characterized mechanism responsible for multidrug resistance involves the expression of the MDR-1 gene product, P-glycoprotein (P-gp). Because the direct inhibition of this protein is very toxic, other methods of multidrug resistance (MDR) regulation have been proposed. The MDR-1 promoter sequence contains a κB site, which is recognized by NF-κB. The aim of this work was to characterize whether NF-κB modulation changes the response of bone marrow-derived cells (BMDCs) to chemotherapy.
Scopus© Citations 8 8 2
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Adipose tissue-derived stem cells expressing cardiac progenitor markers: The best source of mesenchymal stem cells for cardiovascular repair?
(2014)
Navarro Betancourt, Refugio
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Baldassarri Ortego, Bruno
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Urquiza y Conde, F.
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Hernández Gutiérrez, Salomón
At the present time a wide variety of stem cell lineages have been explored for the treatment of ischemic cardiomyopathy; currently, the reference cells for cardiac cell therapy are cardiac stem cells (CSCs), because these cells have a specific differentiation commitment into cardiac tissues [ 1 , 2 , 3 ]. In comparison with other cell types, this intrinsic commitment is inversely related to the capacity to differentiate into diverse tissues (Fig. 1). Despite this efficient differentiation, a specific immunophenotype for CSC identification is yet to be meticulously defined. In addition, the use of CSC in a clinical setting is severely hindered by their availability. These obstacles to the use of CSC for cardiac cell therapy have prompted the search for readily more attainable stem cell sources, even if they have a broader differentiation spectrum, such as mesenchymal stem cells (MSCs).
Scopus© Citations 5 11 1

Hernández Gutiérrez, Salomón

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