Facultad de Ciencias de la Salud - CampCM

City

Ciudad de México

Country

Director

Mario Enrique Rendón Macías

Parent Organisation

Campus Ciudad de México

OrgUnit's Publications

Now showing 1 - 10 of 895

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Detección de una mutación en el gen KCNQ1 (KvLQT1) causante de síndrome de Jervell, Lange-Nielsen en una familia mexicana
(2006-07)
Márquez, Manlio F.
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Hernández-Pacheco, Guadalupe
;
Estrada Mena, Francisco Javier
;
Fabregat, Juan R.
;
Pérez-Vielma, Nadia
Antecedentes: Los síndromes de QT largo son enfermedades hereditarias causadas por mutaciones en los genes que codifican las proteínas de los canales iónicos transmembranales de sodio o potasio. Se han encontrado más de 200 mutaciones en por lo menos seis genes. El síndrome de Jervell y Lange-Nielsen (JLN) es la variedad recesiva de la enfermedad y se asocia con sordera congénita. Estudios recientes sugieren correlaciones fenotipo-genotipo con implicaciones importantes para el diagnóstico y tratamiento de este padecimiento. Métodos: En el presente trabajo se analizó el gen KCNQ1 (KvLQTl) en una familia mexicana afectada por síndrome de JLN, utilizando el método de secuenciación automática. © Archivos de Cardiología de México
2 19Scopus© Citations 8
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Tumores primarios de ámpula de Vater: estadificación prequirúrgica por ultrasonido endoscópico. Estudio de prueba diagnóstica
(2019)
Membrillo-Romero, Alejandro
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De la Fuente-Lira, Mauricio
;
Carvallo-Guevara, Patricia
;
Riojas-Garza, Alberto
Objective: To analyze the accuracy of endoscopic ultrasound (EUS) in the evaluation of ampullary tumors compared to histopathology (HP) staging. Methods: A retrospective diagnostic test study. Patients with ampullary tumors staged by EUS and postpancreatoduodenectomy HP attended during 2012-2018 at tertiary level hospital. ©Cirugía y Cirujanos
1 3Scopus© Citations 4
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Open surgery while wearing night vision goggles
(2010)
Mosso Vázquez, José Luis
;
Stetz, Melba C.
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Gonzalez-Ojeda, Roberto
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Wiederhold, Brenda K.
;
Rodríguez Schlögl, Elizabeth María
Night vision technology is nothing new. In fact, the military rely significantly on this technology during nighttime operations. A surgeon is like a medical soldier in the battlefield. His/her only mission is that of keeping people alive. Due to many technological advances, patients cannot only train on relaxation while visiting their doctors but also get distracted by playing videogames while waiting for them. Furthermore, this virtual reality experience can be enhanced if the patient wears goggles or Head Mounted Displays under dimmed or absence of lights. The purpose of this study was to test if a surgeon could operate when extending into such a dark condition situation, but in the surgical suite. Therefore, a surgeon performed seven open surgeries on rabbits. All surgeries were performed on the thorax and abdomen regions. Specifically, the surgeon was able to perform these surgeries by wearing on his head a micro camera with infrared light and a night vision goggles. The first assistant used this same system while the scrub nurse and the anesthesiologist did not. There were no complications either during or after these procedures. It is possible to make open surgeries wearing a night vision system. Further approaches should be tested with human volunteers. Keywords: Night Vision Goggles, Open Surgery, Cyber-medicine
2 17
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Granulomatous liver disease in a referral center in Mexico city
(Elsevier BV, 2025-07)
Ruiz-Manríquez, Jesús
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Feria-Agudelo, Sandra M.
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Olivas-Martinez, Antonio
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Martínez-Sánchez, Froylan D.
;
Azamar-Llamas, Daniel
Introduction and Objectives: Up to 15 % of liver biopsies may reveal granulomas. The underlying causes vary geographically, with marked differences between high- and low-middle-income countries. No studies have examined the etiology of granulomatous liver disease (GLD) in Mexico. This study aims to describe the etiologic profile and clinical outcomes of patients diagnosed with GLD at a tertiary care center in Mexico. Materials and Methods: Retrospective cohort study of patients diagnosed with GLD by liver biopsy between 2001 and 2017. Results: We identified 133 patients with GLD. The most common causes were infectious diseases (36.1 %, n = 48; including 22 mycobacterial infections), foreign body reactions (21.1 %, n = 28), and autoimmune disorders (15.0 %, n = 20). The overall 6-month survival probability was 90.9 % (95 % confidence interval [CI], 86–95 %), declining to 87.5 % (95 % CI, 82–93 %) at 12 months. Patients with autoimmune etiologies had the best prognosis (100 % survival at 6 and 12 months). In contrast, patients with neoplastic GLD had the poorest outcomes, with survival probabilities of 72.7 % (95 % CI, 50.6–100 %) at 6 months and 63.6 % (95 % CI, 40.7–99.5 %) at 12 months. Patients with idiopathic GLD had a favorable short-term prognosis, with a 12-month survival probability of 92 %. Conclusions: In this cohort, infectious diseases were the most common cause of GLD. Prognosis varied by etiology, with idiopathic cases showing favorable short-term outcomes and neoplastic cases exhibiting poor survival rates. ©The authors ©Annals of Hepatology ©Elsevier.
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Pembrolizumab in Patients with Advanced Urothelial Carcinoma with ECOG Performance Status 2: A Real-World Study from the ARON-2 Project
(2024)
Alessandro Rizzo
;
Fernando Sabino Marques Monteiro
;
Yüksel Ürün
;
Francesco Massari
;
Se Hoon Park
10
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Eficacia del autocuidado en el paciente con diabetes mellitus II por lesiones cutáneas en pie diabético : revisión sistemática
(2019)
Hernández Morales, Ely Gabriela
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Ávila de la Vega, Hennay
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Gómez Martínez, Manuel A.
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López Hernández, Blanca Estela
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Hennay Ávila de la Vega
El presente estudio nace de la incertidumbre y la necesidad de conocer la eficacia del autocuidado en la reducción de complicaciones como la úlcera en las extremidades inferiores en los pacientes con diabetes mellitus tipo II con pie diabético. Objetivo: evaluar la eficacia del autocuidado en el cuidado, prevención y reducción de ulceras de extremidades inferiores en los pacientes con diabetes mellitus tipo ll y pie diabético.
14 19
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Plasma Cell Myeloma Associated with Epstein-Barr Virus Infection in an 11-Year-Old Girl
(2012)
Garcéa-Álvarez, Karla Gisela
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Garibaldi-Covarrubias, Roberto
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Flores-Márquez, Maréa Rosa
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Ortíz Hidalgo, Carlos Federico
Multiple myeloma is extremely rare in children and represents fewer than 1% of all patients with myeloma. We report a case of multiple myeloma in an 11-year-old girl, who presented with a well-differentiated immunoglobulin A/kappa plasmacytoma at the base of the skull at 9 years of age; at that time, the bone marrow biopsy was negative. Two years later, the patient experienced generalized bone pain with multiple lytic bone lesions that affected the skull, long bones, ribs, and clavicle. The bone marrow biopsy showed a well-differentiated (Marschalko-type) multiple myeloma that was positive for CD138 and immunoglobulin A, with kappa light chain restriction. Interestingly, the Epstein-Barr virus (EBV) was detected by in situ hybridization for EBV-encoded RNA (EBER) in the majority of the neoplastic cells from both biopsy specimens. The patient responded favorably to treatment with dexamethasone, thalidomide, and zoledronic acid and is scheduled for bone marrow transplantation. ©Pediatric and Developmental Pathology
2Scopus© Citations 16 3
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Beyond Clinical Signs: The Interplay Between Vagal Tone and Lethargic Behavior in Preterm Infants
(Informa UK Limited, 2025)
Aldrete Cortez, Vania Rocío
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Catano-Cedillo, Liz
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Rendón-Macías, Mario Enrique
In this cross-sectional, observational study, the association between lethargy and vagal tone was analyzed in thirteen low-risk preterm infants. Infants underwent behavioral assessment and vagal tone measurement indexed by high-frequency heart-rate variability (HF-HRV). A lower vagal tone cluster was associated with greater lethargy (p = .05), reduced handling (p = .003), excitability (p = .006), higher skin stress indicators (p = .13), and central nervous system stress indicators (p = .10) than cluster with a higher vagal tone cluster. A lower vagal tone could indicate autonomic nervous system dysregulation or immaturity, leading to neurobehavioral challenges, such as lethargy and further neurodevelopmental difficulties. ©The authors ©Informa UK Limited ©Developmental Neuropsychology.
17Scopus© Citations 2
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Implicaciones bioéticas en el uso de tejido fetal humano obtenido de abortos para la investigación de nuevas vacunas
(2017)
Alcántara Blancarte, Jesica Luz
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Alcántara Blancarte, Jesica Luz
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Aspe-Armella, Virginia
Este trabajo responde a la problemática actual en materia de investigación puesto que se han fabricado y se siguen fabricando vacunas a partir de líneas celulares obtenidas de tejido fetal abortado. El interés de esta investigación está en mostrar algunos argumentos metafísicos, físicos, antropológicos y culturales en torno a las repercusiones éticas que intervienen actualmente en la experimentación con seres humanos, específicamente de la experimentación con tejido fetal abortado para la elaboración de nuevas vacunas.
12 3
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A CRAC-like motif in BAX sequence: Relationship with protein insertion and pore activity in liposomes
(2011)
Martínez-Abundis, Eduardo
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Correa, Francisco
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Rodríguez, Emma
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Soria-Castro, Elizabeth
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Rodríguez-Zavala, José S.
Several proteins that interact with cholesterol have a highly conserved sequence, corresponding to the cholesterol recognition/interaction amino acid consensus. Since cholesterol has been proposed to modulate both oligomerization and insertion of the pro-apoptotic protein BAX, we investigated the existence of such a motif in the BAX sequence. Residues 113 to 119 of the recombinant BAX α5-helix, LFYFASK, correspond with the sequence motif described for the consensus pattern, -L/V-(X)(1-5)-Y-(X)(1-5)-R/K. Functional characterization of the point mutations, K119A, Y115F, and L113A in BAX, was performed in liposomes supplemented with cholesterol, comparing binding, integration, and pore forming activities. Our results show that the mutations Y115F and L113A changed the cholesterol-dependent insertion observed in the wild type protein. In addition, substitutions in the BAX sequence modified the concentration dependency of carboxyfluorescein release in liposomes, although neither pore activity of the wild type or of any of the mutants significantly increased in cholesterol-enriched liposomes. Thus, while it is likely that the putative CRAC motif in BAX accounts for its enhanced insertion in cholesterol-enriched liposomes; the pore forming properties of BAX did not depend on cholesterol content in the membranes, albeit those mutations changed the pore channeling activity of the protein. Copyright © 2011 Elsevier B.V. All rights reserved. © Biochimica et Biophysica Acta (BBA) - Biomembranes
2 7Scopus© Citations 15

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