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    Diffuse Membranous Immunoreactivity of CD56 and Paranuclear Dot-like Staining Pattern of Cytokeratins AE1/3, CAM5.2, and OSCAR in Undifferentiated (Embryonal) Sarcoma of the Liver
    (2010)
    Pérez-Gómez, Rosa María
    ;
    Soria-Céspedes, Danny
    ;
    León-Bojorge, Beatriz de
    ;
    To the editor: Undifferenced (embryonal) sarcoma of the liver (UESL) is an uncommon, rapidly growing malignant spindle cell tumor that usually occurs in children and young adults, as characterized by Stocker and Ishak in 1978. © Applied Immunohistochemistry & Molecular Morphology
    Scopus© Citations 9  2  18
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    Sarcoma histiocítico. Criterios diagnósticos histopatológicos e inmunohistoquímicos y sus diagnósticos diferenciales
    (2011)
    García-Gutiérrez, Mónica
    ;
    Histiocytic sarcoma (HS) is a rare malignant tumor, originating from bone marrow-derived myeloid stem cells, showing morphologic and immunophenotipic evidence of mature tissue histiocytes (macrophages). HS arises in lymph nodes and extranodal sites such as skin, soft tissues and particularly the gastrointestinal tract, often presenting with clinically advanced disease and pursuing and aggressive clinical course. The diagnosis of HS relies predominantly on the immunohistochemical features of the histiocytic lineage, and the exclusion of large cell lymphoma and other poorly differentiated large cell malignancies such as, carcinomas and melanomas.© Gaceta Mexicana de Oncología
      1  8
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    Mujer de 33 años de edad con leve dolor toracoabdominal derecho de seis años de evolución, súbitamente agudizado
    (2011)
    Cárdenas-Escudero, Mara A.
    ;
    Shuchleib-Chaba, Samuel
    ;
    Muruchi-Garrón, Germán Walter
    ;
    León-Bojorge, Beatriz de
    ;
    We present a case of a benign hybrid nerve sheath tumor showing features of both cellular schwannoma and perineurioma. The patient was a 33 year-old female who presented with a 6 month history of pain in the thorax-lumbar region. Axial CT and MIR images showed and homogeneously enhancing solid oval mass involving the left paravertebra region in contact with the vertebral foramina T9-T11. Morphologically the tumor presented a well formed capsule and showed a uniform highly spindle cell proliferation. The spindle cells were arranged in whorls and intersecting fascicles with focal intervening sclerosis and relatively uniform cellularity with a prominent perivascular lymphocytic infiltrate. No cytological atypia, necrosis or mitoses were present. A second cell component was present composed of spindle-shaped cells with inconspicuous bipolar, pale, eosinophilic cytoplasm with oval nuclei. By immunohistochemistry there was a diffuse staining for S-100, and the elongated bipolar cells were EMA, Glut-1 and Claudin-1. To our knowledge this is the first reported case of a hybrid cellular schwannoma/perineurioma. ©Gaceta Médica de México
      2  9
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    Expresión de CD-34 en el elastofibroma. Estudio clinicopatológico, histoquímico e inmunohistoquímico de cuatro casos
    (1999-01)
    Ruelas-Villavicencio, Ana Lilia
    ;
    Aponte Paredes, Paola Susana
    ;
    Objetivo. Explorar la expresión imunohistoquímica de células en casos de elastofibroma y evaluar cuatro técnicas histoquímicas para fibras elásticas. Material y métodos. Se obtuvieron cuatro elastofibromas de los archivos del departamento de patología del Hospital ABC. Todos los pacientes fueron mujeres cuyas lesiones se encontraron en la región subescapular. Se realizó inmunohistoquímica para CD34, actina, desmina, vimentina, proteína S-100 y bcl-2 y se evaluaron cuatro métodos para fibras elásticas (Verhoff, Gallego, Reyes-Mota y Russel-Movat). Resultados. En los cuatro casos habían numerosos miofibroblastos (positivos a la vimentina/actina/desmina). Además encontramos células dendríticas distribuidas irregularmente, positivas al CD34. Las tinciones de Verhoff y Reyes-Mota son las que mejor resaltan el componente elástico. El método de Russel-Movat es útil para distinguir diferentes componentes de tejido conectivo. Conclusión. Las células del elastofibroma originalmente se consideraron fibroblastos. La presencia de vimentina/actina/desmina sugiere que existe una población de miofibroblastos. Describimos por primera vez, células fusiformes y dendríticas, positivas al CD34 (QBend/10) distribuidas irregularmente en toda la lesión. Estas células pueden ser población reactiva de células del ®sistema dendrítico dérmico¼. No encontramos inmunorreactividad para bcl-2 en las células fusiformes y dendríticas © Revista de Investigación Clínica
      2Scopus© Citations 6  11
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    El profesor y la costurera: Un episodio de la vida de Jacob Henle
    Jacob Henle was a great German anatomist and one of the most important histologists of all times. One of the most commonly used eponymous terms in renal histology is the loop of Henle, but many other anatomical and pathological findings are associated with his name. During his stay in Zurich he fell in love with Elise Egolff who worked as a maid and seamstress in the house of one of his friends. No one could ever imagine how the wide social chasm that separated the servant-girl and the professor could be bridged. Henle arranged for his sister Marie to educate Elise and give her social polish. In a short time Elise was transformed into a lady of the world. A year and a half later Jacob and Elise were married. This episode inspired the novelist Auerbach to write the novel “The Professor’s Wife”, and the play “Pygmalion” by George B Shaw. (Gac Med Mex. 2015;151:819-27). © Gaceta Médica de México.
      2  9
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    Small-Cell Plasmacytoma With Prominent Myxoid Stroma Mimicking a Soft-Tissue Neoplasm
    (2009)
    Lara-Torres, César Octavio
    ;
    Gómez-Plata, Eduardo
    ;
    In the majority of cases, histological diagnosis of plasma cell tumor can be made without difficulty; however, a proportion of them can represent a diagnostic challenge due to the wide spectrum of phenotypes that neoplastic plasma cells may exhibit. Numerous cytological and architectural variants have been well documented. Cytological, plasma cell tumors may show small, cleaved, multilobated, monocytoid, pleomorphic, histiocytoid, oncocytic, or clear cells. © International Journal of Surgical Pathology
      2Scopus© Citations 2  12
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    History of Leukemia, Revisited
    (Springer Science and Business Media LLC, 2025)
    Purpose of the Review: Provide a general historical overview of leukemia, emphasizing the early discoveries that led to its characterization. Recent Findings: Leukemia recognition began in the late 19th century with the advent of the microscope. Leeuwenhoek and Swammerdam described erythrocytes, while Lieutaud first observed globuli albicantes, later identified as lymphocytes by Hewson. Early case studies by Velpeau, Donné, Bennett, Craigie, Virchow, and Fuller suggested that leukocytosis could occur without infection. Virchow coined the term “leukemia,” while Bennett proposed “leucocythemia.” Neumann identified the bone marrow as the source of blood cells and leukemia, coining the term “myelogenous leukemia,” and Ehrlich classified leukemia into myeloid and lymphoid types. In 1914, Boveri linked chromosomal abnormalities to cancer, and in 1960, Nowell and Hungerford discovered the Philadelphia chromosome. The use of mustard gas in WWI led to the development of chemotherapy drugs like chlorambucil and busulfan. The Human Genome Project further advanced leukemia diagnosis and treatment. Summary: Leukemia, like many diseases, has evolved due to changes in causative factors such as viruses, bacteria, and genetic mutations, which have impacted its pathogenesis and treatment. It will undoubtedly continue to evolve, with new scientists working towards a cure for this devastating disease. ©The author ©Current Oncology Reports ©Springer Science and Business Media LLC.
      28
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    Hematoxylin: Mesoamerica's Gift to Histopathology. Palo de Campeche (Logwood Tree), Pirates' Most Desired Treasure, and Irreplaceable Tissue Stain
    (2019) ;
    Pina-Oviedo, Sergio
    Hematoxylin is a basic dye derived from the heartwood of Palo de Campeche ( Haematoxylum campechianum), the logwood tree native to Mexico and Central America. Haematoxylum means "bloodwood" in reference to its dark-red heartwood and campechianum refers to its site of origin, the coastal city of Campeche on the Yucatan Peninsula, Mexico. Hematoxylin is colorless but it turns into the color dye hematein after oxidation (ripening). The dyeing property of logwood was well-known to the natives of the Yucatan Peninsula before the arrival of the Spaniards who brought it to Europe shortly after the discovery of the Americas. An important trade soon developed related to growing and preparing hematoxylin for dyeing fabrics. Pirates discovered that one shipload of logwood was equivalent to a year's value from any other cargo, and by 1563, more than 400 pirate vessels wandered the Atlantic Ocean and attacked Spanish galleons transporting gold, silver, and logwood from the Americas to Europe. Hematoxylin and eosin is a staining method that dates back to the late 19th century. In 1865 and 1891, Böhmer and Meyer, respectively, first used hematoxylin in combination with a mordant (alum). Later, with the use of anilines by Ehrlich, the repertoire of stains expanded rapidly resulting in the microscopic descriptions of multiple diseases that were defined by their stainable features. Today hematoxylin, along with eosin, remains the most popular stain in histology.©International Journal of Surgical Pathology
    Scopus© Citations 25  2  7
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    Primary Monophasic Synovial Sarcoma of the Tonsil: Immunohistochemical and Molecular Study of a Case and Review of the Literature
    (2013)
    Soria-Céspedes, Danny
    ;
    Galván-Linares, Aldo Iván
    ;
    Oros-Ovalle, Cuauhtémoc
    ;
    Gaitan-Gaona, Francisco
    ;
    Synovial sarcoma (SS) arises primarily in the lower extremities with a predilection for sites in proximity to large joints, such as the knee. It rarely occurs in the head and neck region, and the tonsil is an unusual site for the tumor, with only eight previously published cases in this anatomical site. We present a case of a primary monophasic SS arising in the right tonsil in a 63-year-old male. His medical history was noncontributory. Immunohistochemistry showed that cytokeratin OSCAR, EMA, Bcl-2, vimentin, PGP 9.5, and TLE1 were diffusely positive. A molecular analysis using RT-PCR indicated that the patient was positive for the SYT/SSX1 fusion transcript. A diagnosis of monophasic synovial sarcoma of the tonsil was made. © Head and Neck Pathology
    Scopus© Citations 16  1  7
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    El diagnóstico histológico e inmunohistoquímico de la neoplasia sólida pseudopapilar de páncreas y su diagnóstico diferencial
    (2019)
    Erráez-Jaramillo, Pablo José
    ;
    Solid pseudopapillary neoplasm of the pancreas is a rare tumor of uncertain histogenesis, described separately by Gruber and Frantz, that accounts for between approximately 1% and 3% of pancreatic neoplasms. It is characterized by a cystic and solid pattern of growth patterns with formation of pseudopapillae. It occurs primarily in young women, although cases in children and older patients and men have been reported. The tumor is of low-grade malignant potential, as the majority of the cases are cured by simple but complete surgical resection. Knowledge of the unique morphologic characteristics of this neoplasm is essential for the correct diagnosis. We review herein the pathologic and immunohistochemical features of this neoplasm and its differential diagnosis with other pancreatic tumors. © Revista Española de Patología
    Scopus© Citations 5  2  5